Class 1 histocompatibility antigens

Doyle A, Martin WJ, Funa K, Gazdar A, Carney D, Martin SE, Linnoila 1, Cuttitta F, Mulshine J, Bimn P Markedly decreased expression of class 1 histocompatibility antigens, protein, and mRNA in human small-cell lung cancer. J Exp Med 1985 161 1135-1151. 

Brown, J.H., Wiley, D.C. The three-dimensional structure of the human class II histocompatibility antigen HLA-DRl. Nature 364 33-39, 1993. 

Paulsson, K. (2004) Evolutionary and functional perspectives of the major histocompatibility complex class I antigen-processing machinery. Cell. Mol. Life Sci. 61, 2446-2460. 

Some patients will have repeatedly nonspecific reactivity in an ELISA assay, since the HIV-1 antigen used for the antibody assays is produced in cultured human T cells. It is not unexpected that occasional false positive assays occur in human sera from individuals with autoimmune diseases a history of multiple pregnancies or multiple transfusions or antibodies to certain class II histocompatibility antigens (especially HLA-DR4). Block reagents have been added to specimen diluents to minimize cross-reactions in these sera. This necessitates the use of confirmatory tests, especially the Western blot. With the use of both ELISA and Western blots, false positives decrease to less than 1 per 100,000. 

Yamano, T. et al. Two distinct pathways mediated by PA28 and hsp90 in major histocompatibility complex class 1 antigen processing. J Exp Med 2002, 396, 185-96. 

Finally, in this brief overview of lymphocyte defects, mention should be made of mutations affecting major histocompatibility-complex (MHC) Class II molecules. These mutations affect a multiprotein transcription factor complex that regulates the expression of MHC Class II molecules (121). Affected patients have undetectable levels of MHC Class II antigens HLA-DP, DQ, and DR on the surface of monocytes and B cells. Lack of these antigen-presenting molecules leads to impaired immune response. Affected individuals have moderate lymphopenia with a severely reduced number of CD4+ T cells and normal or increased numbers of CD8+ T cells. Since MHC molecules in the thymic epithelium play a key role in positive and negative selection of primitive T cells, selection of competent T cells is also affected in the absence of MHC Class II antigens. 

Quijada L, Moreira D, Soto M, Alonso C, Requena JM. Detection of major histocompatibility complex class I antigens on the surface of a single murine blastocyst by immuno-PCR. BioTechniques 1997 24(4) 660-662. 

NE also inhibits the I FNy-induced major histocompatibility (MHC) class II antigen expression in rat astrocytes, which is reduced by propranolol, but not by phentolamine or propranolol, suggesting that the effect of NE might be mediated through (32-adrenoreceptors (Frohman et al., 1988). 

P. M. Kloetzel. Generation of major histocompatibility complex class I antigens functional interplay between proteasomes andTPPII. Nature Immunology, 5 661-669, 2004. 

Simister NE, Mostov KE. Cloning and expression of the neonatal rat intestinal Fc receptor, a major histocompatibility complex class I antigen homolog. Cold Spring Harb Symp Quant Biol 1989 54(Pt l) 571-80. 

Mapping and expression pattern analysis of key components of the major histocompatibility complex class I antigen processing and presentation pathway in a representative human renal cell carcinoma cell line. Electrophoresis 22, 1801-1809. 

Craiu, a., Gaczynska, M., Akopian, T, Gramm, C. F., Fenteany, G., Goldberg, A.L., Rock, K. L., Lactacystm and dasto-lactacystin beta-lactone modify multiple proteasome beta-subunits and inhibit intracellular protein degradation and major histocompatibility complex class 1 antigen presentation. J. Biol. Chem. 1997,... 

J.H. Brown, T.S. Jardetzky, J.C. Gorga, L.J. Stem, R.G. Urban, J.L. Strominger, and D.C. Wiley. 1993. Three-dimensional stmcture of the human class II histocompatibility antigen HLA-DRl Nature 364 33-39. (PubMed)... 

Perry VH (1998) A revised view of the central nervous system microenvironment and major histocompatibility complex class II antigen presentation. J Neuroimmunol 90 113-121. 

Mr 11,800) globular protein located on the surface of virtually all nucleated cells. It is closely related to the class I histocompatibility antigens which consist of a heavy, variable chain and a hght chain that hinds to the heavy chain domain nearest to the cell membrane. The light chain consists of the molecule. Due to its... 

Hess AD, hoburn C Immune tolerance to self-major histocompatibility complex class II antigens after bone marrowtransplan-tation role of regulatory cells. Biol Blood Marrow Transplant 2006 12 518-29. 

It has been shown that a number of peptides linked to the N-terminal end of the diphtheria toxin A-fragment are translocated to the cytosol (Stenmark etai, 1991, Stenmark etal., 1992 Ariansen efal., 1993). It is an interesting question to what extent such peptides can subsequently be presented by class I major histocompatibility antigens. If this is the case, fusion proteins of viral or cancer-related peptides and enzymatically inactive mutants of diphtheria toxin could be used for vaccination purposes to expand desired populations of cytotoxic CD T-lymphocytes. 

Interferony (IFNy) is the major interferon produced by immunologicaUy stimulated (by mitogens or antigens) lymphocyte cultures the primary producer ceUs are T lymphocytes, and the major activity is immunoregulation. IFNy has been implicated in aberrant expression of class II histocompatibility antigens by tissue ceUs (such as thyroid cells) that do not normally express them, leading to autoimmune disease. ... 

Matsumoto, Y. and Fugiwara, M., Absence of donor-type major histocompatability complex class I antigen bearing microglia in the rat central nervous system of radiation bone marrow chimeras, J. Neumimmunol, 17, 71, 1992. 

Tooyama, I., Kimura, H., Akiyama, H., and McGeer, P.L., Reactive microglia express class I and class II major histocompatibility antigens in Alzheimer s disease, Brain Res., 523, 273, 1990. 

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