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Immune-tolerance

Mechanism of peripheral immune tolerance characterized by a state of functional unresponsiveness induced in T cells by suboptimal or partial stimulation. Engagement of the antigen receptor in the absence of costimulation signaling induces anergy in T cells, which become unable to respond to new stimulations. [Pg.1177]

In addition to IL-10, TGF-(3 is a key cytokine in immune tolerance. It was investigated whether orally administered TGF-(3, such as TGF-(3 in human milk, retains and exerts its activity in the intestinal mucosa and can induce immune tolerance to dietary antigens. In a relevant mice model the oral administration of TGF-(3 increased activation and response in TGF-(3-related responsive elements and increased serum TGF-(3 levels [118]. BALB/c mice treated orally with OVA and TGF-(3 showed augmented... [Pg.33]

Sakaguchi S, Yamaguchi T, Nomura T, Ono M Regulatory T cells and immune tolerance. Cell 2008 133 775-787. [Pg.42]

Tolerance is the process that allows organ-specific antigens to be accepted as self.2,6 This would mean that the immune system would cease to respond to the allograft, and immunosuppressive medications would not be necessary. Immune tolerance has not been accomplished successfully in humans.2,6... [Pg.835]

The main goal of recessively inherited coagulation disorder (RICD) treatment is to prevent and control spontaneous and surgery-related bleeding episodes. Specifically, therapeutic options improve hemostasis via replacement of deficient blood coagulation factors while minimizing the development of immune tolerance.20... [Pg.995]

Trautmann A, Akdis M, Kleemann D, Altznauer F, Simon HU, Graeve T, NoU M, Brocker EB, Blaser K, Akdis CA T cell-mediated Fas-induced ker-atinocyte apoptosis plays a key pathogenetic role in eczematous dermatitis. J Clin Invest 2000 106 25-35. Schmidt-Weber CB, Blaser K Regulation and role of transforming growth factor-beta in immune tolerance induction and inflammation. [Pg.5]

Mechanisms involved in UV-B-induced immune tolerance are multiple. UV-B irradiation strongly affects the viability and function of skin DCs [6]. UV-B irradiation causes DNA damage and apoptosis in LCs, while promoting their migration to regional lymph nodes [7]. This effect is paralleled by the reduced expression of MHC and costimulatory molecules, which results in an impaired antigen presenting capability. The release of IL-10 by resident skin cells, ker-atinocytes and mast cells, also contributes to dampen DC function [8, 9]. Thus, upon UV-B irradiation, immature or partially mature DCs,... [Pg.94]

Thatcher TH. Luzina I. Fishelevich R, Tomai MA. Miller RL. Gaspari AA Topical imiquimod treatment prevents UV light-induced loss of contact hypersensitivity and immune tolerance. J Invest Dermatol 2006 126 821-831. [Pg.100]

Cavani A, Nasorri F, Ottaviani C, Sebastiani S, De Pita 0, Girolomoni G Human CD25 + regulatory T cells maintain immune tolerance to nickel in healthy, nonallergic individuals. J Immunol 2003 171 5760-5768. [Pg.100]

Endothelial dysfunction, effects on blood clotting Generation of neoantigens, breakdown in immune tolerance... [Pg.69]

Saito T, Kuang JQ, Bittira B, Al-Khaldi A, Chiu RC. Xenotransplant cardiac chimera immune tolerance of adult stem cells. Ann Thorac Surg 2002 74 19-24 discussion 24. [Pg.123]

Hermeling S, Aranha L, Damen JM, et al. Structural characterization and immunogeni-city in wild-type and immune tolerant mice of degraded recombinant human interferon alpha2b. Pharm Res 2005 22(12) 1997-2006. [Pg.304]

Chimera with Seeming Breakdown of Immune Tolerance, Lancet (1970) 2,1110. [Pg.368]

The Treg cells were previously known as the suppressor T cells and are pivotal in maintaining immune tolerance. Their principal functions include a negative feedback after the generation of an immune response to limit unintended damage and to protect from autoimmunity. These cells are described in detail in Chapter 9. [Pg.11]

SDS PAGE, see electrophoresis Selective immune tolerance, 7 Semi-dry blotting, 236 Sepharose, 33, 274 Sequential epitope, 256 Serum, 35... [Pg.164]

Pleyer, U., Ritter, T. and Volk, H. D. (2000). Immune tolerance and gene therapy in transplantation. Immunol. Today 21, 12-14. [Pg.155]

See other pages where Immune-tolerance is mentioned: [Pg.1429]    [Pg.266]    [Pg.2]    [Pg.94]    [Pg.99]    [Pg.113]    [Pg.150]    [Pg.182]    [Pg.202]    [Pg.205]    [Pg.241]    [Pg.78]    [Pg.405]    [Pg.66]    [Pg.206]    [Pg.70]    [Pg.35]    [Pg.135]    [Pg.142]    [Pg.156]    [Pg.216]    [Pg.217]    [Pg.15]    [Pg.469]    [Pg.470]    [Pg.341]    [Pg.163]    [Pg.172]    [Pg.173]    [Pg.70]    [Pg.71]    [Pg.79]   
See also in sourсe #XX -- [ Pg.405 ]

See also in sourсe #XX -- [ Pg.818 ]



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