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Lymphoid organs

NF-kB is also crucial for the proper functioning of the adaptive immune system not only by acting on the immune cells themselves but also by participating in the development and organization of the secondary lymphoid organs (lymph nodes, spleen, and Peyer s patches), in which both B and T lymphocytes undergo maturation and activation. NF-kB proteins have an important role in lymphocyte development and... [Pg.887]

Tissue-Specific Expression. In the adult rodent, PPARy is expressed in brown and white adipose tissue, and at lower levels in intestine, retina, skeletal muscle, and lymphoid organs. In human, PPARy is most abundantly expressed in white adipose tissue and at lower levels in skeletal muscle, the heart, and liver, but not in lymphoid tissues, although PPARy has been identified in macrophages in human atheromas. [Pg.942]

Similar studies on dimethyltin dichloride and monooctyltin trichloride showed no effects on the lymphoid organs (Seinen et al., 1977a). [Pg.26]

The cells that make up the immune system are distributed throughout the body but are found mainly in the lymphoreticular organs, which may be divided into the primary lymphoid organs, i.e. the thymus and bone marrow, and the secondary or peripheral... [Pg.284]

After activation, cytotoxic T cells emerge from lymphoid organs to infiltrate the graft and trigger the immune response. These cells have been shown to induce graft destruction via two mechanisms (1) secretion of the cytotoxic proteins perforin and granzyme B, and (2) induction of cellular apoptosis... [Pg.833]

Central memory (TCM) CCR7 Used to define these cells and allows entry into secondary lymphoid organs... [Pg.109]

Effector memory (Tem) CCR7 (absent) Lack CCR7 and are thereby excluded from noninflamed secondary lymphoid organs... [Pg.109]

Secondary lymphoid organs CCR7 Entry and localization in T-cell zones... [Pg.110]

Matloubian M, Lo CG, Cinamon G, et al. Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on SIP receptor 1. Nature 2004 427 355-360. [Pg.112]

Forster R, Schubel A, Breitfeld D, et al. CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs. Cell 1999 99 23-33. [Pg.113]

Forster R, Mattis AE, Kremmer E, Wolf E, Brem G, Lipp M. A putative chemokine receptor, BLR1, directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleen. Cell 1996 87 1037-1047. [Pg.114]

Carramolino L, Zaballos A, Kremer L, et al. Expression of CCR9 beta-chemokine receptor is modulated in thymocyte differentiation and is selectively maintained in CD8(+) T cells from secondary lymphoid organs. Blood 2001 97(4) 850-857. [Pg.138]

Ohl L, Henning G, Krautwald S, et al. Cooperating mechanisms of CXCR5 and CCR7 in development and organization of secondary lymphoid organs. J Exp Med 2003 197 1199-1204. [Pg.151]

Cyster JG. Chemokines and cell migration in secondary lymphoid organs. Science 1999 286(5447) 2098-2102. [Pg.185]

Page G, Lebecque S, Miossec P. Anatomic localization of immature and mature dendritic cells in an ectopic lymphoid organ correlation with selective chemokine expression in rheumatoid synovium. J Immunol 2002 168(10) 5333-5341. [Pg.186]

Manzo A, Paoletti S, Carulli M, et al. Systematic microanatomical analysis of CXCL13 and CCL21 in situ production and progressive lymphoid organization in rheumatoid synovitis. Eur J Immunol 2005 35(5) 1347-1359. [Pg.193]

Total and absolute differential leukocyte counts Globulin levels1 and A/G ratios Lymphoid organs / tissues Thymus, spleen (optional lymph nodes)... [Pg.29]


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See also in sourсe #XX -- [ Pg.232 , Pg.238 ]

See also in sourсe #XX -- [ Pg.46 ]

See also in sourсe #XX -- [ Pg.170 ]




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