Single-nucleotide polymorphism array

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Use of Single-Nucleotide Polymorphism Array for Tumor Aberrations in Gene Copy Numbers... 

Key Words single nucleotide polymorphism array allelic imbalance copy nmn-ber variation whole-genome amplification formalin-fixed and parafiin-embedded tissue... 

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Hoque MO, Lee J, Begum S et al. High-throughput molecular analysis of urine sediment for the detection of bladder eaneer by high-density single-nucleotide polymorphism array. Cancer Res 2003 63 5723-5726. 

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Lips EH, Dierssen JW, van Eijk R et al. Reliable high-throughput genotyping and loss-of-heterozygosity detection in formalin-fixed, paraffin-embedded tumors using single-nucleotide polymorphism arrays. Cancer 2005 65 10188-10191. 

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Lieberfarb ME, Lin M, Lechpammer M et al. Genome-wide loss of heterozygosity analysis from laser capture microdissected prostate eaneer using single nucleotide polymorphic allele (SNP) arrays and a novel bioinformaties platform dChipSNP. Cancer Res 2003 63 4781 785. 

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Medintz, I., Wong, W.W., Sensabaugh, G., Mathies, R.A., High speed single nucleotide polymorphism typing of a hereditary haemochromatosis mutation with capillary array electrophoresis microplates. Electrophoresis 2000, 21, 2352-2358. 

Since microarrays are simply spots of DNA arrayed in a known pattern, they also can be used for DNA-DNA hybridization studies. This is the basis for using micro-arrays for comparative DNA hybridizations, single nucleotide polymorphism (SNP) discovery, and chromatin immunoprecipiation followed by microarray chip hybridization (ChIP on chip analyses) to identify transcription factor binding sites (discussed below). 

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