Liver disorders

Hepatic Hepatic means "pertaining to the liver." For example, hepatitis is inflammation of the liver. Liver disorders are sometimes marked by jaundice, a yellowish coloration to the whites of the eyes and skin. Certain chemicals are hepatotoxins (toxic to the liver), usually as a result of chronic exposure. One example is carbon tetrachloride (CCI4). 

Reye syndrome is a rare disorder in children, characterized by a combination of severe liver disorder and encephalopathy (central nervous system (CNS) disturbances) that can follow an acute viral illness and which has a relatively high mortality. It has been found to be... 

The HMG-CoA reductase inhibitors are contraindicated in individuals with hypersensitivity to the drugs, serious liver disorders, and during pregnancy (Pregnancy... 

The anabolic steroids are contraindicated in patients with known hypersensitivity to the dni, liver disorders, or serious cardiac disease, and in men with prostate gland disorders (eg, prostate carcinoma and prostate enlargement). The anabolic steroids are classified as Pregnancy Category X dru and should not be administered during pregnancy and lactation. Anabolic steroids are contraindicated when used to enhance physical appearance or athletic performance... 

Intermediate- or short-acting BZs are preferred for chronic use in the elderly and those with liver disorders because of minimal accumulation and achievement of steady state within 1 to 3 days. 

Kaplowilz, N. (2001). Drug induced liver disorders Implications for drug development and regulation. Drug Information Journal, 35 347 100. 

Some toxic effects are reversible. Everyone has been exposed to some agent, household ammonia for example, that produces irritation to the skin or eyes. Exposure ends and, sometimes perhaps with a delay, the irritation ends. Some readers have no doubt been poisoned on occasion by the ingestion of too much alcohol. The effects here also reverse. The time necessary for reversal can vary greatly depending upon the severity of the intoxication and certain physiological features of the person intoxicated. But most people also realize that chronic alcohol abuse can lead to a serious liver disorder, cirrhosis, which may not reverse even if alcohol intake ceases. This type of effect is irreversible or only very slowly reversible. It is important in making a toxicological evaluation to understand whether effects are reversible or irreversible, because one is obviously much more serious than the other. 

These studies were generally carried out at bile-acid concentrations that occur naturally in humans e.g. for colon cells, after a high-fat meal for esophageal cells, in individuals with repeated heartburn due to duodeno-gastroesophageal reflux or in cholestatic liver disorders). Taken together, these studies indicate that induction of apoptosis by bile acid is likely a frequent challenge for cells throughout the GI tract. 

Milk thistle Ambiguous and uncertain evidence for protection against liver disorders... 

Active hepatic disease, such as acute hepatitis or active cirrhosis if previous methyidopa therapy has been associated with liver disorders coadministration with MAOIs hypersensitivity to any component of these formulations, including sulfites. 

Hepatic effects Fatal and nonfatal liver disorders of an idiosyncratic or hypersensitivity type may occur. At the start of therapy, perform baseline liver function studies. If abnormalities exist, the potential for hepatotoxicity could be enhanced. 

Saudi Arabia. Hot water extract of the dried rhizome is taken orally as a stomachic, a diuretic, a carminative, and an antiemetic and used externally as an antiseptic, anesthetic, and astringent . South Korea. Hot water extract of the dried rhizome is taken orally as an abortifa-cient . Hot water extract of the rhizome, together with Bupleurum falcatum, Scutellaria baicalensis, Panax ginseng, Glycyrrhiza glabra, Zizyphusjujuha, and Pinellia tuberosa, is taken orally for tonsillitis, otitis media, tuberculosis, common cold, liver disorders, chills, fevers, and chest pains . 

Kaplowitz N. (2003). Dmg-Induced Liver Disorders Introduction and Oveview. In N Kaplowitz and L.D. Deleve (Eds.). Drug-Induced Liver Disease. Marcel Dekker,... 

Ranunculus chinensis Bunge. Hui Hui Suan (whole plant) Protoanemonin, anemonin, ranunculin.48 Relieve swelling, asthma, liver disorders, toothache, night blindness. 

Tamarindus indicus L. Luo Huang Zi (Tamarind) (stem, fruit) Tannins, beta-amyrin, campesterol, beta-sitosterol, palmitic acid, oleic acid, linoleic acid, eicosanoic acid, arabinose, xylose, galactose, glucose, uronic acid, pectins, mucilage, vitamin B.60-216 Diuretic, purgative, for liver disorders, inappetence, digestion, and hypoglycemic, hypocholesterolemic properties. 

No difference in nervous system function, blood and respiration was reported in workers exposed by inhalation and via skin contact, but there was some indication of liver disorders among a subgroup of workers (30-39 years old) with more than five years exposure (lARC, 1989). 

Adverse effects of pharmacological doses of androgens include, as one would expect from male hormones, hirsutism with acne and other signs of virilization, along with adverse lipoprotein profiles, endometrial hyperplasia in women, and an increased risk of cardiovascular disease. Some compounds are particularly likely to cause liver disorders. 

II years of treatment without metastasis he was switched to treatment with an LH-RH analogue, which was regarded as safer, but at this time his liver function tests were found to be seriously deranged. Biopsy showed established cirrhosis with steatohepati-tis. He had no history of excessive alcohol intake, and it seemed likely that the diethylstilbestrol was the cause of the liver disorder. 

Broom tops are often used with Agrimony and Dandelion root for dropsy and liver disorders. For this purpose a decoction of 1 ounce each of Broom tops and Agrimony and 1/2 ounce Dandelion root to 3 pints of water simmered down to 1 quart is taken in wineglassful doses every four or five hours. 

Jaundice and other liver disorders, gout and rheumatism. This root, when roasted and ground, is mixed with coffee, to the benefit of drinkers of that beverage. 

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