Liver disease biliary tract disorders

Elevated levels of alkaline phosphatase and GGT occur with obstructive disorders that disrupt the flow of bile from the hepatocytes to the bile ductules, or from the biliary tree to the intestines. Examples of the former include primary biliary cirrhosis and drug-induced cholestasis examples of the latter include gallstone disease and malignancies of the pancreas and bile ducts. In liver disease, the levels of GGT correlate well with elevations of the alkaline phosphatase, and their combination is a sensitive and specific marker for biliary tract disease. ... 

---