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Liver drug-induced disease

Zimmerman H. Drug-induced liver disease. Drugs 1978 16 25-45. [Pg.1846]

Plasma-derived antithrombin concentrates have been used medically since the 1980s for the treatment of hereditary and acquired antithrombin deficiency. Hereditary (genetic) deficiency is characterized by the presence of little/no native antithrombin activity in plasma and results in an increased risk of inappropriate blood clot/emboli formation. Acquired antithrombin deficiency can be induced by drugs (e.g. heparin and oestrogens), liver disease (decreased antithrombin... [Pg.344]

Alkaline phosphatase levels and GGT are elevated in plasma with obstructive disorders that disrupt the flow of bile from hepatocytes to the bile ducts or from the biliary tree to the intestines in condition such as primary biliary cirrhosis, sclerosing cholangitis, drug-induced cholestasis, gallstone disease, and autoimmune cholestatic liver disease. [Pg.254]

See Chapter 40, Drug-Induced Liver Disease, authored by William R. Kirchain and Rondall E. Allen, for a more detailed discussion of this topic. [Pg.977]

Liu, Z.X., Kaplowitz, N., Immune-mediated drug-induced liver disease, Clin. Liver Disease, 6, 755, 2002. [Pg.61]

Laskin, D.L. and Gardner, C.R., Role of sinusoidal cells and inflammatory macrophages in hepatotoxicity, in Drug induced Liver Disease, Kaplowitz, N. and DeLeve, L, Eds., Marcel Dekker, New York, 2002, 183-211. [Pg.120]

We call attention also to the web site for the Drug-Induced Liver Injury Network (DILIN) sponsored since 2003 by the National Institutes of Health (NIH), Liver Disease Branch of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). [Pg.515]

Many patients have underlying liver disease with liver function abnormalities. It may be difficult to determine superimposed drug-induced liver injury in patients with viral hepatitis, passive congestion of the liver from heart failure, fatty liver... [Pg.371]

Bleibel, W., Kim, S., D Silva, K. and Lemmer, E.R. (2007) Drug-induced liver injury review article. Digestive Disease and Sciences, 52, 2463—2471. [Pg.383]

Kaplowitz N. (2003). Dmg-Induced Liver Disorders Introduction and Oveview. In N Kaplowitz and L.D. Deleve (Eds.). Drug-Induced Liver Disease. Marcel Dekker,... [Pg.269]

Of 14 cases of suspected drug-induced liver disease presenting to a gastroenterology department over a 3-year period, one was thought to be related to thiamazole, with a hepatitic pattern of liver function tests in a 39-year-old woman 6 days after the start of therapy recovery was swift and complete (48). Delayed cholestatic hepatitis without antineutrophil cytoplasmic antibodies has been reported (49), and there have been fatal cases of hepatic necrosis (SEDA-21, 438) (7). [Pg.338]

A 50-year-old woman with previous autoimmune thyroid disease taking atorvastatin developed acute hepatitis when she also was given ezetimibe (4). Further investigations, including liver biopsy, showed a probable drug-induced autoimmune hepatitis. [Pg.534]

Argatroban is a small molecule thrombin inhibitor that is FDA approved for use in patients with heparin-induced thrombocytopenia (HIT) with or without thrombosis and coronary angioplasty in patients with HIT. It, too, has a short half-life, is given by continuous intravenous infusion, and monitoring is done by aPTT. Its clearance is not affected by renal disease but is dependent on liver function. The drug requires dose reduction in patients with liver disease. Patients on argatroban will demonstrate elevated INRs because of test interference, rendering the transition to warfarin difficult. [Pg.768]

Li C, Benet L. Mechanistic role of acyl glucuronides. In Kaplowitz N, DeLeve L, eds. Drug-Induced Liver Disease. New York Marcel Dekker, Inc., 2003 151-181. [Pg.347]


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See also in sourсe #XX -- [ Pg.59 , Pg.60 , Pg.61 , Pg.63 ]

See also in sourсe #XX -- [ Pg.1816 ]




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Disease drug-induced

Drug-disease

Drug-induced

Liver diseases

Liver drug-induced

Liver drug-induced disease/damage

Liver inducible

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