Liver cells in vitro

Coumarin did not induce micronuclei in mice in vivo and was not mutagenic in Drosophila melanogaster. It was weakly positive in induction of micronuclei in htunan cells in vitro, but failed to induce tmscheduled DNA synthesis in human liver cells in vitro. Coumarin induced sister chromatid exchanges without metabolic activation and chromosomal aberrations with metabolic activation, but not micronuclei or gene mutations in mammalian cells in vitro. It was mutagenic in only two out of 11 Salmonella typhimurium strains tested, with metabolic activation. 

Sister chromatid exchange, Chinese hamster ovary cells in vitro Sister chromatid exchange, Chinese hamster cells in vitro Sister chromatid exchange, Chinese hamster cells in vitro Sister chromatid exchange, Chinese hamster cells in vitro Sister chromatid exchange, Chinese hamster cells in vitro Sister chromatid exchange, RL4 rat liver cells in vitro Micronucleus formation, Chinese hamster ovary cells in vitro Micronucleus formation, Syrian hamster embryo cells in vitro... 

Methyl methanesulfonate induced DNA single-strand breaks and alkali-labile sites in human lymphocytes in vitro. It induced unscheduled DNA synthesis in human epidermal keratinocytes and in oral epithelial and fibroblast cell cultures. Methyl methanesulfonate induced gene mutations in human lymphoblasts at the hprt locus and sister chromatid exchanges and micronuclei in HepG2 human liver cells in vitro. 

Unscheduled DNA synthesis test with mammalian liver cells in vitro UDS in vitro DNA repair DNA repair synthesis... 

Unscheduled DNA Synthesis Test with Mammalian Liver Cells in vitro... 

The principles of this method are the same as and the procedure similar to that for the above described method Unscheduled DNA Synthesis (UDS) Test with Mammalian Liver Cells in vitro . The differences between the in vivo and the in vitro method are related... 

The purification, structure elucidation, and antihyperlipidemic activities of nine compounds of the decarestrictine family, descarestrictines E to M (53-61), of P. simplicissimum were also reported. All of the compounds exhibited inhibitory effects on cholesterol biosynthesis in HepG2 liver cells in vitro [76]. 

High concentrations of hydroalcoholic green tea extracts have been shown to exert acute toxicity in rat liver cells in vitro. The compound (-)-epigallocatechin-3-gal-late (EGCG) was noted as the constituent that was likely responsible for this effect. The bioavailability of catechins is relatively low with oral ingestion, however, suggesting that EGCG is not responsible for the hepatotoxicity reported in human studies (Schmidt et al. 2005). 

W. Hume, Effect of eugenol on respiration and division in human pulp, mouse fibroblasts, and liver cells in vitro, J. Dent. Res. 63 (1984) 1262-1265. 

APS Aloe barbadensis Miller inhibition of B[a]P binding to DNA in mouse liver cells, in-vitro reduction of oxidative DNA damage inhibition phorbol myristic acetate (PMA)-induced ornithine decarboxylase activity in Balb/3T3 cells and PMA-induced tyrosine kinase activity in human leukemic cells, in-vitro [38]... 

Z.H. Zhou, M. Komiyama, K. Terao, and Y. Shimada, Effects of pectenotoxin-1 on liver cells in vitro. Natural Toxins 2 (1994) 132-135. 

Penninks Seinen (1980) looked at subcellular distribution of dibutyltin in rat liver and thymus cells in vitro. Radioactivity was concentrated in mitochondria and low in cytoplasm in thymus cells, in marked contrast to liver cells, where mitochondrial radioactivity was very low. Differences in cellular distribution have been suggested as a reason for the selective effect on the thymus. 

In genotoxic assays BNA induced unscheduled DNA synthesis in human cells in vitro and chromosomal aberrations, sister chromatid exchanges, DNA strand breaks, and unscheduled DNA synthesis in rodent cells in vitro-, in vivo it formed DNA adducts in bladder and liver cells of dogs. ... 

NMOR is mutagenic in bacterial assays in the presence of activated liver microsomal fractions. However, NMOR did not induce DNA damage in either human or rat kidney cells in vitro as determined by DNA strand breakage. ... 

Chromosomal aberrations, rat liver RL4 eells in vitro Chromosomal aberrations, Syrian hamster embryo eells in vitro Aneuploidy, Chinese hamster liver eells in vitro Mitotie aberrations, Chinese hamster primary liver eells in vitro Aneuploidy, rat liver RL4 eells in vitro Cell transformation, BALB/3T3 mouse eells Cell transformation, BALB/3T3 mouse eells Cell transformation, C3H10T14 mouse eells... 

Cell transformation, RLV/Fiseher rat Cell transformation, SA7/Syrian hamster embryo eells Cell transformation, Syrian hamster embryo eells Unseheduled DNA synthesis, human hepatoeytes in vitro Gene mutation, human lymphoeytes, TK and HPRT loei in vitro Sister ehromatid exehange, human lymphoeytes in vitro Sister ehromatid exehange, human lymphoeytes (metabolie aetivation by eo-eultured with rat liver eells) in vitro Chromosomal aberrations, human lymphoeytes in vitro... 

Micronucleus formation, human Hep-G2 cells in vitro Unscheduled DNA synthesis, human liver slices in vitro Unscheduled DNA synthesis, rat hepatocytes in vivo Micronucleus formation, B6C3Fi mice in vivo... 

Chromosomal aberrations, rat liver epithelial cells in vitro Micronucleus formation, Syrian hamster embryo cells in vitro Cell transformation, Syrian hamster embryo cells in vitro Sister chromatid exchange, human lymphocytes in vitro... 

CIR, Chromosomal aberrations, rat liver RL4 cells in vitro - NT 10 Priston Dean (1985) ... 

Toluene can activate cyclin-dependent kinase 2 in rat liver epithelial (RLE) and HL60 cells in vitro and it also causes hyperphosphorylation of p53 and pRB105 in these cells. These activities are shared with benzene but, unlike benzene, toluene did not increase the p53-DNA site-specific binding in RLE cells (Dees Travis, 1994 Dees et al., 1996). 

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