Antihyperlipidemic activity

The mechanism of action of the antimalarial drugs is uncertain. It has been proposed that antimalarials interfere with T-lymphocyte activation. Other effects of antimalarials that may benefit patients with SLE include inhibition of cytokines, decreased sensitivity to ultraviolet light, anti-inflammatory activity, antiplatelet effects, and antihyperlipidemic activity... 

The purification, structure elucidation, and antihyperlipidemic activities of nine compounds of the decarestrictine family, descarestrictines E to M (53-61), of P. simplicissimum were also reported. All of the compounds exhibited inhibitory effects on cholesterol biosynthesis in HepG2 liver cells in vitro [76]. 

Sodium iV-p-chlorobenzoyl sulphamate (57) has been synthesized and observed to produce potent hypolipidemic activity in rodents107. In a structure-activity study of the antihyperlipidemic activity in mice, eleven different ortho-, meta- and para-substituted benzoylsulphamates (including 57) have been synthesized and in the same study four benzylsulphamates (58) have been reported108. 

Use In cosmetics for moisturizing the skin, for race-mate separation of amines, and as starting material for asymmetric synthesis. The 3,3,5-trimethylcyclohexyl ester, Crilvastatin has antihyperlipidemic activity (HMG-CoA reductase inhibitor). ... 

Ursolic and oleanolic acids have been early described to exert antiinflammatory and antihyperlipidemic activities. Betulinic acid has been reported to exhibit antiretroviral, antimalarial, and anti-inflammatory properties. Thumher and coworkers [183] have demonstrated its cytotoxic activity against a variety of tumor cells originating from the neural crest. It has also... 

Basimy, A. M. M., Arafat, S. M., El-Marzooq, M. A. Antioxidant and Antihyperlipidemic activities of anthocyanins from eggplant peels. J. 

Z H.(2011). Synthesis of new 1,8-naphthalimide derivatives with potential antihyperlipidemic activities. (Under publication). 

Discuss important preadministration and ongoing assessment activities the nurse should perform on the patient taking an antihyperlipidemic drug. 

Microbial natural product chemistiy has generated a number of bioactive natural products. For instance cyclosporine A FK506 and rapamycin are used as immunosuppressants [16]. Other examples of microbial metabolites, having potential biomedical application include antihyperlipidemics, lovastatin and guggulsterone [17, 18]. The crude extracts of Mucor plumbeus exhibited acetylcholinesterase (AChE) enzyme inhibition activity. Our detailed chromatographic work on this crude extract resulted in the isolation of mucoralactone A (11), a novel steroid containing a lactone moeity incorporated in its structure. 

Mechanism of Action An antihyperlipidemic that enhances synthesis of lipoprotein lipase and reduces triglyceride-rich lipoproteins and VLDLs. Therapeutic Effect Increases VLDL catabolism and reduces total plasma triglyceride levels. Pharmacokinetics Well absorbed from the GI tract. Absorption increased when given with food. Protein binding 99%. Rapidly metabolized in the liver to active metabolite. Excreted primarily in urine lesser amount in feces. Not removed by hemodialysis. Half-life 20 hr. 

The fibrates are another class of antihyperlipidemic drug and are frequently coadministered with a statin. Fibrates act as agonists of the peroxisome proliferator-activated receptors (PPAR), particularly PPAR-a. PPARs are nuclear receptors that influence gene expression and lipid metabolism. Examples of fibrates include gemfibrozil (Lopid, A.110) and fenofibrate (Tricor, A.lll) (Figure A.30). Fenofibrate is hydrolyzed in the body to its active form, fenofibric acid (A.112). Fibrates do not decrease LDL levels as effectively as statins, but fibrates do elevate HDL cholesterol levels. 

The bibliographic research shows that flavonoids possess widespread biological activities, including antimicrobial [37-39], antihelmintic [40], mutagenic [41-42], carcinogenic [40,43,44], anticarcinogenic [42,45,46], antioxidant [34, 38, 47, 48], antiinflammatory [49-53], antiallergic [54], antiviral [55, 56], endocrine [57], antihyperlipidemic [58], and antidiarrheic [59-61] properties. 

Chitosan and its derivative exhibited the great antihyperglycemic, antihyperlipidemic, and anti-hypocholesterolemic activities in type 1 and type 2 diabetic animal models. Moreover, chitin, chitosan, and their derivatives exhibited cholesterol-lowering activity in animal and clinical studies. Therefore, chitin, chitosan, and their derivatives can be promising candidates as potential material for protecting diabetes mellitus and lowering the cholesterol absorption. 

The preparation of ammonia-carboxyborane (H3N.BH2CO2H) from the corresponding trimethylamine adduct has been reported. The compound shows antihyperlipidemic and antitumour activity. 

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