Aminoglycosides gentamicin

General Antibacterial Properties. In the clinical control of bacterial infectious disease, the aminoglycosides gentamicin, tobramycin, amikacin, netilmicin, and to a lesser extent, dibekacin and isepamicin are most commonly used for the treatment of serious infections involving aerobic or facultative gram-negative baciUi, especially in the compromised host. This usage is discussed in the Hterature (44—51). 

Treatment with aminoglycosides (gentamicin, tobramycin, and amikacin) can cause non-oliguric intrinsic ARF. Injury is due to the binding of aminoglycosides to proximal tubular... 

Aminoglycosides Gentamicin Streptomycin Spectinomycin Phosphorylation Acetylation Nucleotidylation Efflux Altered target... 

Loffler, D. and Temes, T.A. Analytical method for the determination of aminoglycoside gentamicin in hospital wastewater via liquid chromatography-electrospray tandem mass spectrometry. /. Chromatogr. A. 2003, 1000,583—588. 

Aminoglycosides (gentamicin, amikacin, tobramycin) Phosphate preparations oral, enema, and IV (sodium phosphate, potassium phosphate)... 

Aminoglycosides gentamicin, tobramycin, and amikacin use per sensitivities. Cefoxitin, cefotetan. 

Fosfomycin Parenteral Therapy Aminoglycosides Gentamicin Tobramycin Amikacin Netilmicin Single-dose therapy for uncomplicated infections. Gentamicin and tobramycin are equally effective gentamicin is less expensive. Tobramycin has better pseudomonal activity, which may be important in serious systemic infections. Amikacin generally is reserved for multiresistant bacteria. 

Neutropenic patients—For suspected bacteremia in neutropenic patients, ceftazidime, imipenem, meropenem, or cefepime, each alone or in more seriously ill patients with an aminoglycoside (gentamicin, tobramycin or amikacin), would be a reasonable first choice. 

Organisms that cause community-acquired pneumonia will be susceptible to broad-spectrum jd-lactam antibiotics, macrolides, or a fluoroquinolone, and usually it is not necessary to add an aminoglycoside. Gentamicin (or other aminoglycosides) never should be used as the sole agent to treat pneumonia acquired in the community or as the initial treatment for pneumonia acquired in... 

Aminoglycosides (gentamicin, streptomycin, amikacin, etc.) Formation of enzymes that inactivate drugs via conjugation reactions that transfer acetyl, phosphoryl, or adenylyl groups... 

Increased efforts are being directed towards control of gram-negative organismThe announcement of therapeutic efficacy of the aminoglycoside, gentamicin, together with that of carbenicillin , cephalosporins and others, have raised the hope that such control is attainable. 

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