Peroxidation, lipid diet-induced

Warnholtz et al (1999) reported that lipid peroxidation is induced in the arteries by administration of high-cholesterol diet to rodents. Hypercholesterolemia increases... 

Increasing evidence in both experimental and clinical studies suggests that oxidative stress plays a major role in the pathogenesis of diabetes mellitus. There is evidence for increased levels of circulating ROS in diabetics, as inferred by the increased lipid peroxidation. Streptozotocin-induced diabetic rats maintained on a 0.5% curcumin diet for 8 weeks showed lowered lipid peroxidation in plasma and urine when compared to control diabetic group (Babu and Srinivasan 1995). The effect of chronic curcumin treatment (200 mg/kg) on the oxidative stress in streptozotocin-diabetic rats was studied at four weekly intervals up to 24 weeks (Majithiya and Balaraman 2005). Curcumin treatment significantly reduced lipid peroxidation. 

A neuropathy caused by clioquinol (iodochlorohydroxyquin, chinoform) and enhanced by the formation of a clioquinol ferric chelate which initiates lipid peroxidation, leads to complete degeneration of retinal neuroblasts within a day. Vitamin E has a potent protective action against the effects of the chelate [75]. Peroxidative damage to DNA in rat brain, induced by methyl ethyl ketone peroxide, a potent initiator of lipid peroxidation, was inhibited by addition of vitamin E to the diet of rats [76]. 

In addition to cytochrome P-450 induction, other diet induced metabolic effects are likely to be involved in carcinogenesis. High temperature processing or long-term storage of foods with attendant exposure to oxygen can lead to the formation of lipid peroxides and oxidized sulfur amino acids in the food. The partially oxidized S-amino acids cystine monoxide (CMO) and methionine sulfoxide (MSO) are nutritionally available, but require in vivo conversion to the reduced amino acids at the... 

The results of the present experiments confirmed the earlier observation of Ugazio et al. (17) that feeding a CD diet induces lipid peroxidation of the microsomal membrane lipids in the liver. Similar findings were also reported recently by Ghoshal et al. (35) who demonstrated that in rats fed a CD diet lipid peroxidation of nuclear membrane lipids occurred much earlier than that of microsomal lipids. The significance of the early and selective effects of a CD diet on nuclear membrane is not clear. The onset... 

Effects of Phenobarbital on a CD Diet-induced Lipid Peroxidation... 

Our results of the effects of phenobarbital on the CD-diet-induced lipid peroxidation are analogous to the earlier findings that phenobarbital inhibited a CD diet-induced cell proliferation. Since the combination of phenobarbital and a CD diet resulted in a synergistic effect on promotion, the findings support the notion that the promoting effects of a CD diet and phenobarbital are mediated through different mechanisms. While sustained liver cell... 

Perera MI, Katyal SL, Shinozuka H. 1986. Suppression of choline-deficient diet-induced hepatocyte membrane lipid peroxidation in rats by the peroxisome proliferators 4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio(N-beta-hydroxyethyl)acetamide and di(2-ethylhcxyl)phthalate. Cancer Res 46 3304-3308. 

When guinea pigs were fed diets supplemented with oil related to TOS, the TOS-related oil produced a decrease in lipid peroxidation products with minimal alterations in phospholipids fatty acid composition of liver microsomes (358). TOS is an exogenously induced autoimmune disease in humans, believed to be a... 

Rushmore, T. H., Lim, Y. R, Farber, E., and Ghoshal, A. K., Rapid lipid peroxidation in the nuclear fraction of rat liver induced by a diet deficient in choline and methionine, Cancer Lett., 24, 251, 1984. 

Saccharans A,B,C.D,E, and F Sacchantm officinarum L/Gramineae Aerial parts These products showed hypoglycemic and anti-atherosclerotic activity in mice and rats, respectively [105]. The accumulation of lipid peroxides induced by a high sugar diet was inhibited by combined feeding with a polysaccharide fraction of S. officinarum [106],... 

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