Metabolism induced

SGAs atypical antipsychotics Metabolism Inducers Inhibitors... 

Bourgoin, S., Artaud, F., Enjalbert, A., Hery, F., Glowinski, J., and Hamon, M. (1977) Acute changes in central serotonin metabolism induced by the blockade or stimulation of serotoninergic receptors during ontogenesis in the rat. J. Pharmacol. Exp. Ther., 202 519-531. 

B3a. Baker, H., Frank, O., Hutner, S. H., Aaronson, S, Ziffer, H., and Sobotka, H., Lesions in folic acid metabolism induced by Primidone. Experientia 18, 224-226... 

Plants are the base of the terrestrial food chain. The body tissue of herbivores feeding on these plants, and subsequently of omnivores and carnivores, is dependent on the isotopic composition of the plant material ingested, and therefore reflects the 813C values of either a C3 or C4 biome. The exact values are modified by metabolically induced fractionation as the food is digested and incorporated into different body tissues. At its simplest, it has been assumed... 

B. Wice, D. Menton, H. Geuze, and A.L. Schwartz. Modulators of cyclic AMP metabolism induce syncytiotrophoblast formation in vitro. Exp Cell Res. 186 306-316(1990). 

CN190 Zulet, M. A., A. Barber, H. Garcin, P. Higueret, and ]. A. Martinez. Alterations in carbohydrate and lipid metabolism induced by a diet rich in coconut oil and cholesterol in a rat model. J Am Coll Nutr 1999 18(1) 36-42. 

Rash risk in 5%-10% Rarely, life-threatening rash (including Stevens-Johnson syndrome) Risk minimized by low starting dose and slow titration Metabolism inhibited by valproate Metabolism induced by carbamazepine... 

Metabolism inducible. Susceptible to inhibition of metabolism by CYP2C9. Highly bound to plasma proteins. Anticoagulation response altered by drugs that affect clotting factor synthesis or catabolism. 

Digoxin susceptible to alteration of gastrointestinal absorption. Digitalis toxicity may be increased by drug-induced electrolyte imbalance (eg, hypokalemia). Digitoxin metabolism inducible. Renal and nonrenal excretion of digoxin susceptible to inhibition. 

Metabolism inducible. Enterohepatic circulation of estrogen may be interrupted by alteration in bowel flora (eg, due to antibiotics). 

Metabolism inducible. Inhibits CYP2D6. Renal excretion susceptible to changes in urine pH. Additive effects with other agents that prolong the QTC interval. 

Susceptible to inhibition of hepatic metabolism by CYP1A2. Metabolism inducible. 

Thus, fetal liver from primates has a more well-developed metabolic system for xenobiotics than does that from rodents and rabbits, for example. This may be due to the late development of the smooth endoplasmic reticulum and therefore of cytochrome(s) P-450 in the latter species. The use of metabolic inducers and inhibitors in vivo and the use of metabolizing systems with embryo or limb bud culture in vitro have all indicated that for some teratogens,... 

Forkert. P.G, Stringer, V. Racz. W.J. (1986b) Effects of administration of metabolic inducers and inhibitors on pulmonary toxicity and covalent binding by 1,1-dichloroethylene in CD-I mice. Exp. mol. Pathol., 45, 44-58... 

Cushman, J.C., Michalowski, C.B. Bohnert, H.J. (19906). Developmental control of crassulacean acid metabolism inducibility by salt stress in the common ice plant. Plant Physiology 94, 1137-42. 

The major change in yeast metabolism induced by casamino acids supplementation was the marked increase in xylitol production, being the major metabolic product by D. hansenii grown in supplemented concentrated medium (Fig. 2B). Both arabitol and xylitol production in yeast are described to be augmented under stress conditions. Arabitol is usually found as a product of arabinose metabolism in oxygen-limited conditions (8,22), but arabitol production is not restricted to arabinose metabolism,... 

Libersa CC, Brique SA, Motte KB, et al. Dramatic inhibition of amiodarone metabolism induced by grapefruit juice. Br J Clin Pharmacol 2000 49(4) 373-378. 

A variety of responses can be initiated by the direct interaction of metals with cellular components. Membrane damage and enzyme inhibition are examples of such a metal effect. Above a certain threshold concentration of metals in the cell, its physiological state is irreversibly changed (Van Assche et al., 1988). This response is reflected by an increase in capacity (activity under non-limiting substrate and coenzyme concentrations) of certain enzymes. This increase in capacity is generally called enzyme induction. These secondary, indirect effects of metals are considered to play an important role in the stress metabolism induced by toxic metal concentrations. 

Table 6-2. Enzymes of the intermediary metabolism induced after application of toxic concentrations of metals. Most of the experiments were performed on Phaseolus vulgaris cultivars, except those who are specially marked, which were performed on Glycine max (1) and on a zinc resistant (2) and a zinc sensitive (3) clone of Silene cucubalus (after Van Assche and Clijsters, 1990b, adapted).

Rise and decay kinetics of metabolically-induced transients,... 

Glick SD, Carlson JN (1989) Regional changes in brain dopamine and serotonin metabolism induced by conditioned circling in rats effects of water deprivation, learning and individual differences in asymmetry. Brain Res 504 231-237. 

Pereira C, Santos MS, Oliveira C (1999) Involvement of oxidative stress on the impairment of eneigy metabolism induced by A beta peptides on PC 12 cells protection by antioxidants. Neurobiol Dis 6 209-219... 

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