Leukemia virus growth

Klement, V., Rowe, W., Hartley, J. and Pugh, W. (1969) Mixed culture cytopathogenicity A new test for growth of murine leukemia viruses in tissue culture. Proc. Natl. Acad. Sci, USA 63, 753-758. 

Tomita M, Kawakami H, Uchihara JN, Okudaira T, Masuda M, Takasu N, Matsuda T, Ohta T, Tanaka Y, Ohshiro K, Mori N. 2006. Curcumin (diferuloylmethane) inhibits constitutive active NF-kappaB, leading to suppression of cell growth of human T-cell leukemia virus type I-infected T-cell lines and primary adult T-cell leukemia cells. Int J Cancer 118 765-772. 

Pretazettine (395) has been the subject of numerous biological studies, and it has been shown to exhibit a number of interesting activities (96,97,101,178-187). For example, 395 was found to inhibit HeLa cell growth as well as protein synthesis in eukaryotic cells by interfering with the peptide bond formation step (97,101). Furthermore, pretazettine inhibited the purified RNA-dependent DNA polymerase (reverse transcriptase) from avian myeloblastosis virus, a typical C-type virus (178), in an unusual fashion since it physically combined with the polymerase enzyme itself rather than interacted with the nucleic acid template. Pretazettine also exhibited antiviral activity against the Rauscher leukemia virus in mouse embryo cell cultures by suppressing viral replication (179). 

To find whether the reduced foci formation was due to inhibition of MSV (M) replication, the effect of these compounds on virus growth was studied. Secondary mouse embryo cell cultures were infected with MSV (M) at the rate of 0.03 competent MSV infectious units per cell and treated with the compounds at different doses after the infection by the focus assay in the presence of an optimal amount of MLV (M) (1.01 10s Leukemia Vims Helper Units) according to Hirschman etal.33 Similarly treated uninfected cultures were trypsinized at the same time, and cells were counted. 

Methyl vinyl ether-MA copolymer has the property of inducing interferon production in animals, which is potentially useful for inhibiting the growth of Friends leukemia virus.The 2 1 divinyl ether-co-MA polyanion cyclopolymer, often referred to as PYRAN, has had extensive study, because of its antitumor and interferon inducer properties. Many structural modifications and derivatives of this copolymer also exhibit antitumor activity, interferon inducing capacity, and a wide spectrum of biological activity. Recent... 

Live vaccines rarely may cause severe or fatal reactions as a result of uncontrolled replication (growth) of the vaccine virus. This may occur in persons with weak immune systems, including persons with leukemia or human immunodeficiency virus (HIV) infection or persons undergoing treatment with certain drugs. This is why it is so important to know a person s health status before giving a live vaccine. 

Anionic polyelectrolytes have been shown to enhance resistance to bacteria and fungi, enhance immune response, inhibit adjuvent arthritis and either depress or stimulate phagocytic activity of the reticuloendothelial system [458,459]. Carboxylic acid polymers have shown interferon induction, antiviral activity, and tumor growth inhibition [460]. The effects include inhibition of sarcoma, leukemia, polyoma and vesicular stomatitis virus. In one application, the cytotoxicity of bleomycin toward cultured mammalian cells was synergisti-cally enhanced by stirring in the presence of high molecular weight polyfacrylic acid) [461]. 

PHOSPHORYLA TWN chronic myelongenous leukemia-associated KIO BCR-ABL Drosophila Kr protein hepatitis B virus core and precore antigens human c-fos protein human c-myc protein human EGF receptor human epidermal growth factor receptor (tyrosine kinase domain) human immunodeficiency virus p24 human immunodeficiency virus tat protein human insulin receptor 6-subunit human insulin receptor - tyrosine kinase domain... 

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