Interferon inducing property

Kakiuchi, N., Marck, C., Rousseau, N., Leng, M., De Clerq, E. and Guschlbauer, W. (1982) Polynucleotide helix geometry and stability. Spectroscopic, antigenic and interferon-inducing properties of deoxyribose-, ribose-, or 2 -deoxy-2 -fluororibose-containing duplexes of poly(inosinic acid), poly(cytidylic acid). J. Biol. Chem., 257, 1924-1928. 

The present evidence indicates that molecular weight iS an important factor in controlling the interferon-inducing property or the toxicity factor of the DVE-MA copolymer. The development of a method which would permit fractionation of the copolymer into fractions of narrow molecular weight distribution for further evaluation as an interferon inducer was the purpose of the investigation undertaken by Butler and Wu [49]. Two copolymer samples having i/j i, = 1.56 dl/g and 0.15 dl/g were subjected to fractionation as the polyelectrolyte on one 3 ft column each, in series, of Type AX, BX, CX, DX and EX Deactivated Porasil, without much success. However, by conversion of the copolymers to their dimethyl ester, it was possible to fractionate these derivatives on standard Styragel columns, and to compare the... 

Methyl vinyl ether-MA copolymer has the property of inducing interferon production in animals, which is potentially useful for inhibiting the growth of Friends leukemia virus.The 2 1 divinyl ether-co-MA polyanion cyclopolymer, often referred to as PYRAN, has had extensive study, because of its antitumor and interferon inducer properties. Many structural modifications and derivatives of this copolymer also exhibit antitumor activity, interferon inducing capacity, and a wide spectrum of biological activity. Recent... 

Lockart Jr., R. Z. (1973). In Interferons and Interferon Inducers (ed N. B. Finter), Criteria for acceptance of a viral inhibitor as an interferon and a general description of the biological properties of known interferons, pp. 11-27. North-Holland Publishing, Amsterdam. 

Contents E.J.Ariens, A.-M.Simonis Design of Bioactive Compounds. -T.J.Bardos Antimetabolites Molecular Approaches for Designing Antiviral and Antitumor Compounds. -T.A.Connors Alkylating Agents. -E.De Clercq Synthetic Interferon Inducers. - C.Woenckhaus Synthesis and Properties of Some New NAD Analogues. 

A sample of poly (2,2-diraethyl-4,7-dihydro-l,3-dioxepin-alt-maleic anhydride) polymers was fractionated and briefly examined for antiviral properties (31). The copolymer was fractionated through Amicon filters into a 1,000-10,000 and 10,000-30,000 molecular weight cuts. Both molecular weight fractions were examined for effect against mice inoculated (ip) with 106 Ehrlich Ascites tumor cells. Five days after inoculation the animals were sacrificed and total peritoneal exudate cells were counted with a hemo-cytometer. Under these conditions, Ottenbrite (31) showed that the 1,000-10,000 molecular weight fraction of the ID-MA copolymer was as effective as Pyran (control in experiment) for control of Ehrlich Ascites tumor cells. Pyran, the copolymer of divinyl ether-MA is a well known antitumor agent (32) and interferon inducer (33). 

Neun, R., Richter, M. F., Staeheli, P., and Schwemmle, M. (1996). GTPase properties of the interferon-induced human guanylate-binding protein 2. FEBS Lett. 390, 69-72. 

An interferon-antagonistic substance has been extracted from mouse costal cartilage, and in addition to its anti-interferon effect, it has been shown to share many properties of plant lectins. 2-Amino-2-deoxy-D-glucose and 2-amino-2-deoxy-D-galactose, but not their respective 2-acetamido-deriva-tives, D-glucopyranosyluronic acid and L-rhamnose, are efficient inhibitors of the anti-interferon-induced cell agglutination. 

Composition of HA with RNA - interferon inducer (0.15% RNA and 1% HA) is the greatest interferon activator in the animals. The mechanism of action is likely related to the fact that the polysaccharide macromolecule blocks some molecular inflanunatory factors such as CD44 and RNAMM [93,94], has some anti-tumour properties [81] and activates the metabolism and proliferation of normal cells. It is also a possible direct effect of biopolymer on the synthesis of interferon by lymphocytes and monocytes through activation of CD44 in these cells [91]. 

The antiviral properties of alternating AT-vinylpyrrolidone-co-MA have received a fair amount of study. The copolymer is known as an interferon inducer.A large number of amino acids, such as histamine, atropine, and prednisolone, have been used to modify the copolymer to obtain additional antiviral, antibacterial, antiinflammatory, and hormonal active materials.The acrylic acid-co-MA polymer has also been modified to obtain antiviral materials. 

Pharmacokinetics The pharmacokinetic properties of Infergen have not been evaluated in patients with chronic hepatitis C. Pharmacokinetic profiles were evaluated in normal, healthy volunteer subjects after subcutaneous injection of interferon alfacon-1 at doses up to 9 j,g. Plasma levels of interferon alfacon-1 at any dose were too low to be detected. However, analysis of Infergen-induced cellular products— induction of 2 5 oligoadenylate synthetase and (beta)-2 microglobulin—after treatment in these subjects revealed a statistically significant, dose-related increase in the area under the curve (AUC). 

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