Lederle Laboratories

Lederle Laboratories Division, American Cyanamid Company Pearl River, New York... 

Oncology and Immunology Research Section, Medical Research Division, Lederle Laboratories, American Cyanamid Company,... 

Prevnar Pneumococcal 7-valent conjugate vaccine Lederle laboratories Immunization to prevent invasive pneumococcal disease... 

Current address Lederle Laboratories, American Cyanamid Corporation, Pearl River, NY 10965... 

The era of feed additive antibiotics had its beginning in the late 1940 s in a classic example of serendipity. Investigators at the Lederle Laboratories were searching for a more convenient source of "animal protein factor", a substance found in liver and other animal proteins that stimulated the growth of chicks fed a vegetable diet (1). [It had already been demonstrated by workers... 

The discovery of the imidazolinotte herbicides had its beginnings in a random screening test some 12 years ago. The phthalimide 1 prepared originally as an anticonvulsant at Cyanamid s Lederle Laboratories had sufficient herbicidal activity to warrant the synthesis of additional members of this series. One of these, the chloro analog was essentially devoid of herbicidal activity but had instead a pronounced... 

In the United States, the manufacturers of fermentation-derived tetracyclines (1), (2), and (3) are the Lederle Laboratories, a division of American Cyanamid Company. Charles Pfizer Inc.. Bristol Laboratories, and Rachelle Laboratories. There are also several manufacturers abroad. Tetracycline is now sold generically by many companies. Pfizer s doxycycline (6) and Lederle s minocycline (7). both semisynthetic tetracyclines, are the only members of the group that have increasing sales. Table I lists the commercial tetracyclines and the corresponding trade names. 

Department of Chemistry, New York University, New York, NY 10003 Department of CNS Research, Medical Research Division of American Cyanamid Company, Lederle Laboratories, Pearl River, NY 10965... 

A. Kende, Organic Chemical Research Section, Lederle Laboratories, New York, U.S.A. 

Tetracyclines. In 1948, a broad-spectrum antibiotic, chlortetracycline (Aureomycin), was introduced by the Lederle Laboratories, a... 

We thank Lederle Laboratories Mallinckrodt Medical, Inc. the Burroughs-Wellcome Company the ACS Division of Inorganic Chemistry, Inc. and Mitch s Tavern for financial support. 

K. F. Bernady and co-workers6 3 from the Lederle Laboratories have described a useful procedure for the synthesis of dl-1 l-deoxy-3-thiaprostanoids based upon the conjugate addition of E-l-alkenyl ligands from lithium E-l-alkenyltrialkyl-alanate reagent 3 to the sulfur containing cyclopentenone (2)64 ... 

Azo-17oi-methyl-17 -hydroxy-5oi-androstane. This derivative (Methyldiazirinol, D-150, Lederle Laboratories) was reported [123] to possess 300% of the anabolic and 20% of the androgenic potency of 17a-methyltestosterone when administered orally. 

Epsilon-Amino-n-Caproic Acid (EACA), C.P., homogeneous (Mann Research Labs.) in concentration of O.IM 0.4 ml per experiment was added. Plasminogen, human, purified (Mann Research Labs.) in concentration of 1 mg/ml VS (15 RPMI units/mg) 0.4 ml was added per experiment. Approximately 44-45 unit amounts (dissolved in VS) of Streptokinase (SK), 100,000 Christensen units/vial. 0.1 mg = 400 units (Lederle Laboratories) was used per experiment. Trypsin Inhibitor, Soybean (SBTI), chromatographic (component VI, salt free, lyoph.), 10,000 BAEE units of inhibition per mg (Mann Research Labs.), was... 

Pneumococcal vaccines produced by different manufacturers are currently available, for example Pneumovax 23 produced by Merck Sharp Dohme and Pnu-Imune 23 produced by Lederle Laboratories. Each vaccine dose (0.5 ml) contains 25 pg of each polysaccharide antigen. Immunization is recommended for people who are at increased risk of developing pneumococcal disease because of underlying chronic health conditions and for older people. About 50% of vaccinees develop mild adverse effects, such as erythema and pain at the injection site. Fever, myalgia, and severe local reactions have been reported in under 1% of vaccinees. Severe systemic reactions, such as anaphylaxis have been rarely reported. 

Lederle Laboratory Division J. T. Baker Chemical Co. Baldwin-Lima-Hamilton Corp. Beckman Instruments, Inc., Scientific and Process Instruments Division Borden Co. 

All tetracycline, 6-demethyltetracycline, declomycin, and chlortetracycline standards were provided by Lederle Laboratories as the hydrochloride salts. All fast atom bombardment spectra were obtained with a VG (Manchester, UK) ZAB SE equipped with a cesium ion gun operated at 30 kV. The optimum matrix was "magic bullet" with a methanol solvent. (Structure2)... 

Osmylation of an a,/8-unsaturated ketone was a key step in the synthesis of triamcinolone by Bernstein s group at the Lederle Laboratories. The starting material, cortisol 21 -acetate 3,20-bisethyleneketal (1), reacted with thionyl chloride in pyridine... 

Arnold L. Oronsky and Jan W.F. Wasley, Pharmaceuticals Div., CIBA-GEIGY Corp., Summit, NJ Present Address Lederle Laboratories, Pearl River, NY... 

Materials. The following were obtained from commercial sources Swims medium S77, horse serum, and fetal calf serum (Grand Island Biologicals) MTX (Lederle Laboratories) was purified by DEAE cellulose prior to use (11) crystalline BSA, poly-L-lysine (M 35,000), hypoxanthine and thymidine (Sigma Chemical Co.) 1-etnyl-3-(3 -dimethylaminopropyl)carbodiimide hydrochloride (EDC) (Story Chemicals) folinic acid (ICN Pharmaceuticals) Blue Dextran (Pharmacia). The concentrations of the folate derivatives and MTX were determined by their respective extinction coefficients (13). MTX-BSA was synthesized according to a previously described procedure ( ) in which MTX is coupled via a terminal carboxyl group to -amino groups contained in the albumin molecule. 

---