American Cyanamid Lederle Laboratory Division

Lederle Laboratories Division, American Cyanamid Company Pearl River, New York... 

The synthesis of these five isomeric peptides (I-V in Table VII) was carried out by a group working at Lederle Laboratories Division of the American Cyanamid Co. (24,81,82,83,426,427,428) (diagram 1 to 6.)... 

In 1948, a broad-spectrum antibiotic, chlortetra-cycline (Aureomycin), was announced from the Lederle Laboratories, Division of American Cyanamid Company. This antibiotic is produced by Streptomyces aureofaciens when grown under submerged aerobic conditions on media composed of sugar, cornsteep liquor, and mineral salts. The crystalline compound has a golden yellow color, which suggested the trade name. 

Oncology and Immunology Research Section, Medical Research Division, Lederle Laboratories, American Cyanamid Company,... 

In the United States, the manufacturers of fermentation-derived tetracyclines (1), (2), and (3) are the Lederle Laboratories, a division of American Cyanamid Company. Charles Pfizer Inc.. Bristol Laboratories, and Rachelle Laboratories. There are also several manufacturers abroad. Tetracycline is now sold generically by many companies. Pfizer s doxycycline (6) and Lederle s minocycline (7). both semisynthetic tetracyclines, are the only members of the group that have increasing sales. Table I lists the commercial tetracyclines and the corresponding trade names. 

Department of Chemistry, New York University, New York, NY 10003 Department of CNS Research, Medical Research Division of American Cyanamid Company, Lederle Laboratories, Pearl River, NY 10965... 

---