Screening random

Taylor, R. Simulation analysis of experimental design strategies for screening random compounds as potential new drugs and agrochemcials./. Chem. Inf. Comput. Sci., 1995, 35,59-67. 

Taylor, R. Simulation Analysis ofExperimental Design Strategies for Screening Random Compounds as Potential New Drugs and Agrochemicals. J. Chem. Inf.Comput. Sci.,... 

Over the past few years, a number of strategies have been developed to screen random peptide libraries for sequences targeting specific proteins. Peptides with desired binding properties can be serially selected and amplified based on a physical link with the encoding cDNA. These technologies include mRNA/DNA, viral, ribosomal, and cell displays with phage display being by far the most commonly used and probably the best understood. 

Design Strategies for Screening Random Compounds as Potential New Drugs and Agrochemicals. 

Key words Phage display, Protein-protein interactions, High-throughput screening. Random combinatorial approach... 

Birch reduction the partial reduction of benzene to 1,4-cyclohexadiene. blind screen (random screen) the search for a pharmacologically active compound without any information about which chemical structures might show activity. 

During the task, 0-mark and X-mark of visual stimulus are displayed on the screen randomly. Subjects were asked to count 0-mark within a duration given and report the counted number at the end of the task. 

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