Kaposi’s sarcoma herpesvirus G-protein-coupled receptor

Burger M, Burger JA, Hoch RC, Oades Z, Takamori H, Schraufstatter IU. Point mutation causing constitutive signaling of CXCR2 leads to transforming activity similar to Kaposi s sarcoma herpesvirus-G protein-coupled receptor. 1 Immunol 1999 163(4) 2017-2022. 

Gershengom MC, Geras-Raaka E, Varma A, Clark-Lewis I. Chemokines activate Kaposi s sarcoma-associated herpesvirus G protein-coupled receptor in mammalian cells in culture. J Clin Invest 1998 102(8) 1469-1472. 

Ho, H. H., Du, D., and Gershengom, M. C. (1999). The N terminus of Kaposi s sarcoma-associated herpesvirus G protein-coupled receptor is necessary for high affinity chemokine binding but not for constitutive activity. J. Biol. Chem. 274, 31327-31332. 

Geras-Raaka, E., A. Varma, H. Ho, I. Clark-Lewis, and M.C. Gershengorn. Human interferon-gamma-inducible protein 10 (IP-10) inhibits constitutive signaling of Kaposi s sarcoma-associated herpesvirus G protein-coupled receptor. J Exp Med 188 405-8, 1998. 

Schwarz M, Murphy PM. Kaposi s sarcoma-associated herpesvirus G protein-coupled receptor con-stitutively activates NF-kappa B and induces proinflammatory cytokine and chemokine production via a C-terminal signaling determinant. J Immunol 2001 167(1) 505-13. 

Lupu-Meiri M. Constitutive signaling by Kaposi s sarcoma-associated herpesvirus G- protein-coupled receptor desensitizes calcium mobilization by other receptors. J Biol Chem 2001 276(10) 7122-8. 

Montaner S. The Kaposi s sarcoma-associated herpesvirus G protein-coupled receptor promotes endothelial cell survival through the activation of Akt/protein kinase B. Cancer Res 2001 6l(6) 264l-8. 

Geras-Raaka, E., Arvanitakis, L, Bais, C., Cesarman, E., Mesri, E.A., and Gershengom, M.C. (1998) Inhibition of constitutive signaling of Kaposi s sarcoma-assodated herpesvirus G protein-coupled receptor by protein kinases in mammalian cells in culture. The Journal of Experimental Medicine, 187, 801-806. 

Carmon, M Philpott, N.J., and Cesarman, E. (2003) The Kaposi s sarcoma-assodated herpesvirus G protein-coupled receptor has broad signaling effects in primary effusion lymphoma cells. Journal of Virology, 77, 57-67. 

Bais, C., Van Geelen, A., Eroles, P., Mudu, A., Chiozzini, C., Dias, S., Silverstein, R.L., Rafii, S. et al. (2003) Kaposi s sarcoma associated herpesvirus G protein-coupled receptor immortalizes human endothelial cells by activation of the VEGF receptor-2/KDR. Cancer Cell, 3, 131-143. 

Bais C, Santomasso B, Coso O, et al. G-protein-coupled receptor of Kaposi s sarcoma-associated herpesvirus is a viral oncogene and angiogenesis activator. Nature 1998 391(6662) 86-89. 

Kirshner, J.R., Staskus, K., Haase, A., Lagunoff, M., Ganem, D., 1999. Expression of the open reading frame 74 (G-protein-coupled receptor) gene of Kaposi s sarcoma (KS)-associated herpesvirus implications for KS pathogenesis. J. Virol. 73, 6006-6014. 

Cesarman R Kaposi s sarcoma-associated herpesvirus contains G protein-coupled receptor and cyclin D homologs which are expressed in Kaposi s sarcoma and malignant lymphoma. J Virol 1996 70(ll) 8218-23. 

Geras-Raaka E. Kaposi s sarcoma-associated herpesvirus (KSHV) chemokine vMIP-II and human SDF-lalpha inhibit signaling by KSHV G protein-coupled receptor. Biochem Biophys Res Commun 1998 253(3) 725-7. 

Shepard LW. Constitutive activation of NF-kappa B and secretion of interleukin-8 induced by the G protein-coupled receptor of Kaposi s sarcoma- associated herpesvirus involve G alpha(13) and RhoA. J Biol Chem 2001 276(49) 45979-87. 

Smit MJ. Kaposi s Sarcoma-Associated Herpesvirus-Encoded G Protein-Coupled Receptor ORF74 Constitutively Activates p44/p42 MAPK and Akt via G(i) and Phospholipase C-Dependent Signaling Pathways. J Virol 2002 76(4) 1744-52. 

ORF, open-reading frame NA, not available KS, Kaposi s sarcoma KSHV, Kaposi s sarcoma-associated herpesvirus GPCR, G protein-coupled receptor CMV, cytomegalovirus MCMV, mouse cytomegalovirus MCK, murine cytomegalovirus chemokine CCL5, CC chemokine ligand 5 IFN, interferon IL, interleukin NF-kB, nuclear factor kB Tp, T helper NK, natural killer. 

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