CC chemokine activities

CC chemokine activities are mediated by seven-transmembrane domain, Gprotein-coupled receptors (see Chap. 2). The CC chemokine receptors are structurally homologous. While the transmembrane and the second and third intracellular/ cytoplasmic domains of these receptors are well conserved, the NH2- and COOH-... 

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Bursill, C.A., Cai, S., Channon, KM., and Greaves, D.R. (2003) Adenoviral-mediated delivery of a viral chemokine binding protein blocks CC-chemokine activity in vitro and in vivo. Immunobiology, 207, 187-196. 

Fig. 2. Oligomerization of CC chemokines. (A) Dimeric form of CCL4 (MIP-ip). (B) Tetrameric form of CCL2 (MCP-1) highlighting both CC dimerization (left) and CXC dimerization (right). (C) CCL20 forms liver and activation regulated chemokine (LARC) a CXC dimer.

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Ott TR, Pahuja A, Nickolls SA, Alieva DG, Struthers RS. Identification of CC chemokine receptor 7 residues important for receptor activation. J Biol Chem 2004 279(41) 42383-42392. 

Tian Y, New DC, Yung LY, et al. Differential chemokine activation of CC chemokine receptor 1-regulated pathways ligand selective activation of Galpha 14-coupled pathways. Eur J Immunol 2004 34(3) 785-795. 

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Abi-Younes S, Si-Tahar M, Luster AD. The CC chemokines MDC and TARC induce platelet activation via CCR4. Thromb Res 2001 101(4) 279-289. 

Fitzhugh DJ, Naik S, Gonzalez E, Caughman SW, Hwang ST. CC chemokine receptor 6 (CCR6) is a marker for memory T cells that arrest on activated human dermal micro vascular endothelium under shear stress. J Invest Dermatol 2000 115(2) 332. 

Niwa R, Shoji-Hosaka E, Sakurada M, et al. Defucosylated chimeric anti-CC chemokine receptor 4 IgGl with enhanced antibody-dependent cellular cytotoxicity shows potent therapeutic activity to T-cell leukemia and lymphoma. Cancer Res 2004 64 2127-2133. 

Struyf S, Proost P, Schols D, et al. CD26/dipeptidyl-peptidase IV down-regulates the eosinophil chemotactic potency, but not the anti-HIV activity of human eotaxin by affecting its interaction with CC chemokine receptor 3. J Immunol 1999 162 4903 1909. 

Liang M, Mallari C, Rosser M, et al. Identification and characterization of a potent, selective, and orally active antagonist of the CC chemokine receptor-1. J Biol Chem 2000 275 19000-19008. 

CC Chemokine Receptor 2 (CCR2) is a member of the G protein-coupled receptor (GPCR) superfamily that serves as the receptor for monocyte chemoattractant proteins 1-4 (MCP-1 to -4), a group of pro-inflammatory chemotactic cytokines (chemokines). CCR2 is the primary chemokine receptor on inflammatory monocytes, and is also expressed on T-cells, dendritic cells, and endothelial cells. Upon ligand engagement, CCR2 mediates both cellular movement and activation. 

Turner, S.J. Domin, J. Waterfield, M.D. Ward, S.G. Westwick, J. The CC chemokine monocyte chemotactic peptide-1 activates both the class I p85/ pllO phosphatidylinositol 3-kinase and the class II PI3K-C2a. J. Biol. Chem., 273, 25987-25995 (1998)... 

Alternative macrophage activation-associated CC chemokine (AMAC)-l... 

Thymus- and activation-regulated chemokine (TARC) Thymus-expressed CC chemokine (TECK)... 

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