Kaposi’s sarcoma-associated

Kledal TN, Rosenkilde MM, Coulin F, et al. A broad-spectrum chemokine antagonist encoded by Kaposi s sarcoma-associated herpesvirus. Science 1997 277 1656-9. 

Gershengom MC, Geras-Raaka E, Varma A, Clark-Lewis I. Chemokines activate Kaposi s sarcoma-associated herpesvirus G protein-coupled receptor in mammalian cells in culture. J Clin Invest 1998 102(8) 1469-1472. 

Bais C, Santomasso B, Coso O, et al. G-protein-coupled receptor of Kaposi s sarcoma-associated herpesvirus is a viral oncogene and angiogenesis activator. Nature 1998 391(6662) 86-89. 

Stedman W, Deng Z, Lu F, Lieberman PM (2004) ORC, MCM, and histone hyperacetylation at the Kaposi s sarcoma-associated herpesvirus latent replication origin. J Virol 78 12566-12575 Steiner H, Haass C (2001) Nuclear signaling a common function of presenilin substrates J Mol Neurosci 17 193-198... 

Moore, P. S., and Chang, Y. (2001) Molecular virology of Kaposi s sarcoma-associated herpesvirus. Philos. Trans. R. Soc. Lond. B Biol. Sci. 356,499-516. 

Kaposi s sarcoma-associated herpesvirus Bcl-2 homolog low molar mass DNA cell cycle mitosis phase... 

Cattani P, Capuano M, Graffeo R, Ricci R, Cerimele F, Cerimele D, Nanni G, Fadda G. Kaposi s sarcoma associated with previous human herpesvirus 8 infection in kidney transplant recipients. / Clin Microbiol 2001 39 506-8. 

Ho, H. H., Du, D., and Gershengom, M. C. (1999). The N terminus of Kaposi s sarcoma-associated herpesvirus G protein-coupled receptor is necessary for high affinity chemokine binding but not for constitutive activity. J. Biol. Chem. 274, 31327-31332. 

Same laser for Raman and one optical tweezers 780 nm Healthy and tumor infected cells causing Kaposi s sarcoma-associated herpesvirus (KSHV) Intensities of the bands at 1,004, 1,093, and 1,663 cm were altered Detection of cancer infected cells. Large study with 85% sensitivity and 92.5% specificity in blind tests to diagnose cancer. Biological relevance of KSHV infection upon cell signaling was investigated... 

Hamdeu KE et al (2005) Spectroscopic aualysis of Kaposi s sarcoma-associated herpesvirus iufected cells by Ramau tweezers. J Virol Methods 129(2) 145-151... 

Cesarman E, Knowles DM. Kaposi s sarcoma-associated herpesvirus a lymphotropic human herpesvirus associated with Kaposi s sarcoma, primary effusion lymphoma, and multicentric Castleman s disease. Semin Diagn Pathol 1997 14 54-66. 

HHV-8 has been isolated from Kaposi s sarcomas of AIDS patients. This Kaposi s sarcoma-associated herpes virus (KSHV) produces chemokine-like gene products called vMIP-I and vMIP-II (Table 8). 

Sharma-Walia, N., Raghu, H., Sadagopan, S., Sivakumar, R., Veettil, M. V., Naranatt, R R, Smith, M. M., and Chandran, B. (2006). Cyclooxygenase 2 induced by Kaposi s sarcoma-associated herpesvirus early during in vitro infection of target cells plays a role in the maintenance of latent viral gene expression. J Virol 80(13), 6534-6552. 

Ely SA, Powers J, Lewis D, et al. Kaposi s sarcoma-associated herpesvirus-positive primary effusion lymphoma arising in the subarachnoid space. Hum Pathol. 1999 30 981-984. 

PRIMARY EFFUSION LYMPHOMA " A neoplasm induced by human herpes virus 8 (Kaposi s sarcoma-associated... 

Nador RG, Cesarman E, Chadburn A, et al. Primary effusion lymphoma a distinct clinicopathologic entity associated with the Kaposi s sarcoma-associated herpes virus. Blood. 1996 88(2) 645-656. 

Cesarman E, Chang Y, Moore PS, et al. Kaposi s sarcoma-associated herpes virus-like DNA sequencing in age-related body cavity lymphoma. N Engl J Med. 1995 332 1186-1191. 

Geras-Raaka, E., A. Varma, H. Ho, I. Clark-Lewis, and M.C. Gershengorn. Human interferon-gamma-inducible protein 10 (IP-10) inhibits constitutive signaling of Kaposi s sarcoma-associated herpesvirus G protein-coupled receptor. J Exp Med 188 405-8, 1998. 

Various viruses encode proteins with sequenee homology to host proteins which are known to be involved in host defense functions. Viruses pirate and modify key immunoregulatory molecules, by use of molecular mimicry, to elude the Immune system (Murphy, 1997). Viruses also encode proteins that exploit or alter their host cells, replicate or induce migration for virus dissemination. Interestingly, DNA viruses such as the Herpesviruses (Cytomegalovirus (CMV), human herpesvirus (HHV-6 and 7), herpesvirus Saimiri (HVS) and Kaposi s sarcoma-associated Herpesvirus (KSHV)) all express GPCRs (Table 2). 

Bais, C., Santomasso, B., Coso, O., Arvanitakis, L., Raaka, E.G Gutkind, J.S., Asch, A.S., Cesarman, E., Gerhengorn, M.C., Mesri, E.A., 1998. G-protein-coupled receptor of Kaposi s sarcoma-associated herpesvirus is a viral oncogene and angiogenesis activator. Nature 391, 86-89. 

Boshoff, C., Whitby, D., Hatziioannou, T., Fisher, C Walt, J., Hatzakis, A., Weiss, R., Schulz, T 1995b. Kaposi s-sarcoma-associated herpesvirus in HIV-negative Kaposi s sarcoma. Lancet 345, 1043-1044. 

Etoposide is used primarily in treatment of testicular tumors in combination with bleomycin and cispiatin, and in combination with cispiatin and ifosfamide for small-cell carcinoma of the lung. It also is active against non-Hodgkin s lymphomas, acute nonlymphocytic leukemia, and Kaposi s sarcoma associated with AIDS. Etoposide has a favorable toxicity profile for dose escalation in that its primary acute toxicity is myelosuppression. In combination with ifosfamide and carboplatin, it is frequently used for high-dose chemotherapy in total doses of 1500 to 2000 mg/m. ... 

---