K562

Theodorakis, N.G., Zand, D.J., Kotzbauer, P.T., Williams, G.T., Morimoto, R.I. (1989). Hemin induced transcriptional activation of the hsp70 gene during erythroid maturation in K562 cells is due to a heat shock factor mediated stress response. Mol. Cell. Biol. 9,3166-3173. 

K562 (erythroleukemic cells) BITC > MSoPlTC MS3B1TC > eHBlTC > pHBlTC Nastruzzi et al. (82)... 

The human DNA in this SRM comes from a female (K562) cell line and a male (TAW) source. The cells and DNA are provided as ... 

Wang HY, Cai B, Cui CB, Zhang DY, Yang BF. Vitexicarpin, a flavonoid from Vitex trifolia L, induces apoptosis in K562 cells via mitochondria-controlled apoptotic pathway. Yao Xue Xue Bao 2005 40 27-31. 

Numerous studies have demonstrated that degradation products of (3-carotene exhibit deleterious effects in cellular systems (Alija et al., 2004, 2006 Hurst et al., 2005 Salerno et al., 2005 Siems et al., 2003). A mixture of (3-carotene degradation products exerts pro-apoptotic effects and cytotoxicity to human neutrophils (Salerno et al., 2005 Siems et al., 2003), and enhances the geno-toxic effects of oxidative stress in primary rat hepatocytes (Alija et al., 2004, 2006), as well as dramatically reduces mitochondrial activity in a human leukaemic cell line, K562, and RPE 28 SV4 cell line derived from stably transformed fetal human retinal pigmented epithelial cells (Hurst et al., 2005). As a result of degradation or enzymatic cleavage of (3-carotene, retinoids are formed, which are powerful modulators of cell proliferation, differentiation, and apoptosis (Blomhoff and Blomhoff, 2006). 

Stimulation of murine peritoneal macrophages with IFNy and LPS induced NO synthesis and activated IRE binding by IRP-1 and IRP-2. This activation is NO dependent and accompanied by a loss of the aconitase activity of IRP-1. This was also shown to occur in other cell types, such as the erythroid cell line K562, rat brain slices and mouse fibroblast lines and did not require cytokine stimulation. The activating effects of NO may depend on a direct interaction with the 4Fe-4S cluster or a slow effect on the low-molecular-weight iron pool. Activation of IRP-2 by LPS and IFN-y has not been universally confirmed (reviewed by Cairo and Pietrangelo, 2000). 

Moreb JS, Schseder M, Gray B, Zucali J, Zori R. In vitro selection for K562... 

Sipe, D.M., Jesurum, A., and Murphy, R.F. (1991) Absence of Na+, K+-ATPase regulation of endosomal acidification in K562 erythroleukemia cells./. Biol. Chem. 266, 3469. 

P2Y receptors are activated by adenine and uridine nucleotides. Most of the known P2Y receptors have been detected in the nervous system [21]. The majority of P2Y receptors inhibit neuronal N-type Ca2+ channels and M-type K+ channels. P2Y1 receptors are found exclusively on platelets, on their precursor megakaryocyte cells and on certain other cultured hematopoietic cells, such as K562 leukemia cells. They can be distinguished from other P2 receptors in that ADP is the most potent natural agonist and ATP is a competitive antagonist. ADP acts via a G protein to inhibit cyclic AMP accumulation, mobilize intracellular Ca2+ and stimulate granule secretion. ADP... 

Li J, Xu LZ, Yao JJ, Guo WJ, Xia P, Chen Y (2001a) Reversal effects of droloxifene on multidrug resistance in adriamycin-resistant K562 cell line. Acta Pharmacol Sin 22(11) 1023—1027... 

The thioglycosylated meso-tetraarylporphyrins 124(o,p) (A-C) photocytotoxicities were evaluated against K562 chronic leukaemia cell lines.81... 

Xiao H, Yang LS, Zou HF, Yang L, Le XC (2007) Analysis of oxidized multi-walled carbon nanotubes in single K562 cells by capillary electrophoresis with laser-induced fluorescence. Anal Bioanal Chem 387 119-126. 

We have used human leukemias (HL-60 and K562), murine leukemia (L1210) and human breast cancer (MCF-7) for most of our studies. 

Nucleolin Homo sapiens erydu oleukemia cell line K562 Glycosaminoglycan stabilisation Glycosaminoglycans... 

SAF-A Homo sapiens HeLa, Embryonic kidney cell line 293, K562 Activator Organization of chromosomal DNA packaging of hnRNA p300, DNA PK... 

Fig. 7. Chemical structure of azumamide A-E and activity against the crude enzyme extract from K562 cells. ...

As for the indole alkaloids harmaline and harmine (Fig. 4), their biosynthesis was stimulated in emhryogenic callus of T. terrestris at concentrations of 66.4 0.5 and 82.7 0.6 /rg/g dw, respectively." Harmaline stimulates the central nervous system while harmine is cytotoxic to human leukemia cell lines HL-60 and K562. 

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