Erythroleukemia cells

Hensold, J.O., Hunt, C.R., Calderwood, S.K., Housman, D.E., Kingston, R.E. (1990). DNA binding of heat shock factor to the heat shock element is insufficient for transcriptional activation in murine erythroleukemia cells. Mol. Cell Biol. 10, 1600-1608. 

Sistonen, L., Sarge, K.D., Phillips, B., Abravaya, K., Morimoto, R.I. (1992). Activation of heat shock factor 2 during hemin-induced differentiation of human erythroleukemia cells. Mol. Cell. Biol. 12,4104-4111. 

Included among other differentiating cell lines which have been established in culture, is the human promyelocytic cell line HL-60, which differentiates into more mature myeloid cells upon treatment with retinoic acid and prostaglandin E] (PGEi). Friend erythroleukemia cells differentiate into hemoglobin-producing cells when treated with either dimethyl sulfoxide, or hexamethylene bis-acetamide. 

Wall, D. B Kachman, M. T Gong, S. Y. S Parus, S. J Long, M. W Lubman, D. M. (2001). Isoelectric focusing nonporous silica reversed-phase high-performance liquid chromatog-raphy/electrospray ionization time-of-flight mass spectrometry a three-dimensional liquid-phase protein separation method as applied to the human erythroleukemia cell-line. Rapid Commun Mass Sp. 15(18), 1649-1661. 

Sipe, D.M., Jesurum, A., and Murphy, R.F. (1991) Absence of Na+, K+-ATPase regulation of endosomal acidification in K562 erythroleukemia cells./. Biol. Chem. 266, 3469. 

One of the first HDAC inhibitors to be identified and characterized was sodium butyrate, where it was found to alter the histone acetylation state (Riggs et al, 1977), and further determined to inhibit HDAC activity both in vitro and in vivo (Candido et al, 1978). Almost a decade later trichostatin A (TSA), a fungistatic antibiotic, was found to induce murine erythroleukemia cell differentiation (Yoshida et al, 1987). To date, a wide range of molecules have been described that inhibit the activity of Class I and Class II HDAC enzymes, and with a few exceptions, can be divided into structural classes including (1) small-molecule hydroxamates, such as TSA, suberoylanilide hydroxamic acid (SAHA), scriptaid and oxamflatin (2) short-chain fatty-acids, such as sodium butyrate, sodium phenylbutyrate and valproic acid (VPA) (3) cyclic tetrapeptides, such as apicidin, trapoxin and the depsipeptide FK-228 and (4) benzamides, such as MS-275 and Cl-994 (for reviews see Remiszewski et al, 2002 Miller et al, 2003). Some of these molecules are represented in Fig. 4. 

Yoshida M, Nomura S, Beppu T (1987) Effects of trichostatins on differentiation of murine erythroleukemia cells. Cancer Res 47(14) 3688-3691 Yoshida M, Kijima M, Akita M, Beppu T (1990) Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A. J Biol Chem 265(28) 17174-17179 Yu ZX, Li SH, Nguyen HP, Li XJ (2002) Huntingtin inclusions do not deplete polyglutamine-containing transcription factors in HD mice. Hum Mol Genet 11(8) 905-914. 

Yoshida M, Nomura S, Beppu T. (1987) Effects of trichostatins on differentiation of murine erythroleukemia cells. Cancer Res 47 3688-3691. 

Riggs, M.G., Whittaker, R.G., Neumann, J.R. and Ingram, V.M. (1977) Butyrate causes histone modification in HeLa and Friend erythroleukemia cells. Nature, 268, 462-464. 

Partially purified nudear extract from K562 erythroleukemia cells... 

Sklar MD, Prochownik EV (1991) Modulation of cisplatinum resistance in friend erythroleukemia cells by c-myc. Cancer Res 51 2118-2123... 

Slapak CA, Daniel JC, Levy SB (1990) Sequential emergence of distinct resistance phenotypes in murine erythroleukemia cells under adriamycin selection decreased anthracycline upt e precedes increase P-glycoprotein expression. Cancer Res 50 7895-7901... 

In 1990, researchers at Bristol-Myers Squibb reported the isolation of Bmy-41950 (322) from S. staurosporeus strain R10069 (ATCC 55006). This isolate showed in vitro activity against human colon cancer cells (HCT-116) (307). Two years later, Isono et al. reported the isolation of the same natural product from a different Streptomyces sp., S. platensis subsp. malvinus RK-1409 and named it RK-1409 (7-oxostaurosporine) (322) (308,309). In nature, this isolate was obtained in its optically active form [ Id + 38.3 (c 0.06, CHCI3) (309). The PKC inhibitor RK-1409 (7-oxostaurosporine) inhibited the morphological change of a human erythroleukemia cell line, K-562, induced by phorbol 12,13-dibutyrate (PDBu), and also showed a weak antimicrobial activity against Chlorella vulgaris and Pyricularia oryzae (308). 

S. Phosphatidylinositol-3-kinase activation and atypical protein kinase C z phosphorylation characterize the DMSO signaling in erythroleukemia cells. Cell. Signal., 12, 667-672 (2000)... 

Funk, C. D., Funk, L. B., Kennedy, M. E., Pong, A. S., Fitzgerald, G. A. Human platelet/erythroleukemia cell prostaglandin G/H synthase cDNA cloning, expression, and gene chromosomal assignment, FASEB J. 1991, 5, 2304-2312. 

Rittenhouse, A. R., Vandorpe, D. H., Brugnara, C., and Alper, S. L. 1997. The antifungal imidazole clotrimazole and its major in vivo metabolite are potent blockers of the calcium-activated channel in murine erythroleukemia cells. 1. Membr. Biol. 157 177-191. 

Ginsberg BH, Chatterjee P, Yorek MA. Insulin sensitivity is increased in Friend erythroleukemia cells enriched in polyunsaturated fatty acid. Receptor 1991 1 155-166. 

Hellevuo K, Yoshimura M, Kao M, Hoffman PL, Cocker DMF, Tabakoff B. A novel adenylyl cyclase sequence clcmed from the human erythroleukemia cell line.Biodiem Biophys Res Commun 1993 192 311-8... 

Matsuda K, Matfaur RS, Duaic E, Haludika PV. Androgen regulation of thromboxane A/prostagladin receptor expression in human erythroleukemia cells. Am J Physiol 1993 26S E928-34... 

ZuckerT-P, HigaduoraK, Madur RS, Halusfaka PV. Anihostenedione inoreases thrond>oxane Aj receptors in human erythroleukemia cells. Life Sd 1996 58 683-90... 

HELLEVUO K, YOSHIMURA M, KAO M, HOFFMAN PL, COOPER DM, TABAKOFF B (1993) A novel adenylyl cyclase sequence dcmed from the human erythroleukemia cell line. Biochemical < Biofdtysical Research Communications, 192,311-318. 

Sheth SB, Biradavolu R, Brennan KJ, Colman RW Isolation and regulation of the cGMP-inhibited cAMP diosphodiesterase in human erythroleukemia cells. Thromb Haemost 77 lSS-162,1997. 

Picard, V. Epsztejn, S. Santambrogio, P. Cabantchik, Z. 1. Beaumont, C. Role of ferritin in the control of the labile iron pool in murine erythroleukemia cells. J. Biol. Chem. 273 15382-15386 1998. 

Toth, I. Yuan, L. Rogers, J. T. Boyce, H. Bridges, K. R. Hypoxia alters iron-regulatory protein-1 binding capacity and modulates cellular iron homeostasis in human hepatoma and erythroleukemia cells. J. Biol. Chem. 274 4467-4473 1999. 

Kotkow KJ, Orkin SH. 1995. Dependence of globin gene expression in mouse erythroleukemia cells on the NF-E2 heterodimer. Mol. Cell. Biol. 15(8) 464CM7... 

Nagai T, Igarashi K, Akasaka J, Fu-ruyama K, Fujita H, et al. 1998. Regulation of NF-E2 activity in erythroleukemia cell differentiation. J. Biol. Chem. 273 5358-65... 

Sigounas, G., Hooker, J.L., Li, W., Anagnostou, A. and Steiner, M. (1997b) S-allylmercapto-cysteine, a stable thioallyl compound, induces apoptosis in erythroleukemia cell lines. Nutr. Cancer. 28 153-159. 

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