Ionotropic

D,L-CC-amino-3-hydroxy-5-methyl-4-isoxa2ol Ionotropic glutamate receptors [77521-29-0] C7H10N2O4 (174)... [Pg.550]

NMD A receptors are selectively activated by A/-methyl-D-aspartate (NMD A) (182). NMD A receptor activation also requires glycine or other co-agonist occupation of an allosteric site. NMDAR-1, -2A, -2B, -2C, and -2D are the five NMD A receptor subunits known. Two forms of NMDAR-1 are generated by alternative splicing. NMDAR-1 proteins form homomeric ionotropic receptors in expression systems and may do so m situ in the CNS. Functional responses, however, are markedly augmented by co-expression of a NMDAR-2 and NMDAR-1 subunits. The kinetic and pharmacological properties of the NMD A receptor are influenced by the particular subunit composition. [Pg.551]

Forskolin (5-[acetyloxy]-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-penta-methyl-[3R- 3a-4aP, SP, 6P, 6aa,10a, lOaP, 10ba -lFf-naphtho[2,l-b]pyran-l-one) [66575-29-9] M 410.5, m 229-232°, 228-233°. Recrystd from CfiH6-pet ether. It is antihypertensive, positive ionotropic, platelet aggregation inhibitory and adenylate cyclase activating properties [Chem AbstrS9 1978 244150, de Souza et al. Med Res Rev 3 201 1983]. [Pg.246]

Ionotropic Glutamate Receptors Voltage-dependent Ca2+ Channels Voltage-gated K+ Channels... [Pg.130]

Ferreira VM, Frausto S, Browning MD et al (2001) Ionotropic glutamate receptor subunit expression in the rat hippocampus lack of an effect of a long-term ethanol exposure paradigm. Alcohol Clin Exp Res 25 1536-1541... [Pg.486]

GABAergic System Glycine Receptors Ionotropic Glutamate Receptors Nicotinic Receptors Local Anaesthetics... [Pg.535]

Glutamate Receptors Ionotropic Glutamate Receptors Metabotropic Glutamate Receptors... [Pg.552]

Monyer H, Jonas P, Rossier J (1999) Molecular determinants controlling functional properties of AMPARs and NMDARs in the mammalian CNS, chapter 9 Ionotropic glutamate receptors in the CNS. Springer Verlag... [Pg.661]

Serotoninergic System GABAergic System Ionotropic Glutamate Receptors Glycine Receptors... [Pg.661]

Kainate receptors are a subtype of ionotropic glutamate receptors that are permeable to Na+, K+ and Ca2+ ions. [Pg.671]

Ionotropic Glutamate Receptors Nicotinic Receptors Non-selective Cation Channels K+ Channels... [Pg.690]

Long-term potentiation (LTP) is a synaptic plasticity phenomenon that corresponds to an increase in the synaptic strength (increase in the post-synaptic response observed for the same stimulation of the presynaptic terminals) observed after a high frequency stimulation (tetanus) of the afferent fibres. This increased response is still observed hours and even days after the tetanus. The phenomenon is often observed at glutamatergic synapses and involves, in most cases, the activation of the V-methyl D-aspartate (NMDA) subtype of ionotropic glutamate receptors. [Pg.704]

For differentiation of G-protein-coupled receptor sub-types from subtypes permanently linked to ion channels (ligand-gated ion channels) the terms metabotropic versus ionotropic receptors, respectively, are used. Prime examples of metabotropic receptors are given by the lnGlu receptor family of G-protein-coupled glutamate receptors. [Pg.763]

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