Ionotropic glutamate receptors structure

Six functional families of ionotropic glutamate receptor subunit can be defined by structural homologies 273... 

McFeeters, R. L. and Oswald, R. E. (2002) Structural mobility of the extracellular ligandbinding core of an ionotropic glutamate receptor. Analysis of NMR relaxation dynamics. 

Hollmann, M Structure of ionotropic glutamate receptors in Ionotropic glutamate receptors in the CNS, edited by P. Jonas and H. Monyer, H., Handbook of Experimental Pharmacology 1999, 41, 1-98. 

Figure 30-24 Chemical structures of some agonists of ionotropic glutamate receptors (iGluR).

Kainate receptors (KAR) are heteromeric ionotropic glutamate receptors that play a variety of roles in the regulation of synaptic network activity. KAR are composed of five different subunits designated as GluR5, GluR6, GluR7, KA1, and KA2. These subunits have molecular masses of 100 kDa. The primary structure of KA... 

McFeeters RL, Oswald RE. Emerging structural explanations of ionotropic glutamate receptor function. FASEBJ. 2004 18 428-438. 

Fig. 1 Structures of subunits (top) and subunit oligomerization (bottom) in ligand-gated ion channels. (a) P2X receptor family, (b) Ionotropic glutamate receptor family, (c) TRPV channel family, (d) Cys-loop superfamily comprising nAChRs, 5-HT3,GABAa, and glycine receptors.

Kew JN, Kemp JA. 2005. Ionotropic and metabotropic glutamate receptor structure and pharmacology. Psychopharmacology (Berl) 179 4-29. 

Fig. 1. Domain structure of ionotropic glutamate receptors (iGluRs) showing the four major components of mammalian iGluRs and the transmembrane topology. Bacterial iGluRs do not have the ATD and the C-terminal domain, and kainate binding proteins from lower vertebrates do not have the ATD. Note that SI and S2 refer to segments of the primary sequence whereas, Lobes 1 and 2 refer to protein folding units. Both Lobes 1 and 2 are made up of pordons of both SI and S2.

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