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Glycine receptors, ionotropic

GABAergic System Glycine Receptors Ionotropic Glutamate Receptors Nicotinic Receptors Local Anaesthetics... [Pg.535]

Serotoninergic System GABAergic System Ionotropic Glutamate Receptors Glycine Receptors... [Pg.661]

There are two main families of ligand-gated ion channel proteins that act as ionotropic receptors. One family includes the nicotinic acetylcholine receptor, the GABA-A receptor, the glycine receptor, and a class of serotonin receptor. The other family comprises various types of ionotropic glutamate receptors. Since these various ligand gated ion channels are activated by neurotransmitters, the medicinal chemistry of these proteins is presented in detail in chapter 4. [Pg.432]

Fig. 1 Structures of subunits (top) and subunit oligomerization (bottom) in ligand-gated ion channels. (a) P2X receptor family, (b) Ionotropic glutamate receptor family, (c) TRPV channel family, (d) Cys-loop superfamily comprising nAChRs, 5-HT3,GABAa, and glycine receptors. Fig. 1 Structures of subunits (top) and subunit oligomerization (bottom) in ligand-gated ion channels. (a) P2X receptor family, (b) Ionotropic glutamate receptor family, (c) TRPV channel family, (d) Cys-loop superfamily comprising nAChRs, 5-HT3,GABAa, and glycine receptors.
When comparing transmitter-gated ion channels on a functional level, one can discern between anion and cation channels. The former ones comprise the GABAa and glycine receptors, which display a rank order of anion selectivity of I- > Hr > Cl- and which are also permeable to HC()3. All other ionotropic receptors mentioned here are cation channels, which discriminate rather poorly between various monovalent cations, at least when compared with voltage-gated ion channels. Some... [Pg.484]

Inhibitory glutamate receptors (iGlu-Rs) are inhibitory, Glu-gated ion channels related to the ionotropic GABA receptors and glycine receptors, the open channel being permeable to Cl- and sometimes to K+. The isoxazole alkaloid ibotenic acid activates iGlu-Rs (Table 3.3). [Pg.90]

NMD A receptors are selectively activated by A/-methyl-D-aspartate (NMD A) (182). NMD A receptor activation also requires glycine or other co-agonist occupation of an allosteric site. NMDAR-1, -2A, -2B, -2C, and -2D are the five NMD A receptor subunits known. Two forms of NMDAR-1 are generated by alternative splicing. NMDAR-1 proteins form homomeric ionotropic receptors in expression systems and may do so m situ in the CNS. Functional responses, however, are markedly augmented by co-expression of a NMDAR-2 and NMDAR-1 subunits. The kinetic and pharmacological properties of the NMD A receptor are influenced by the particular subunit composition. [Pg.551]

The NMDA receptor is an ionotropic glutamate receptor involved in fast excitatory neurotransmission. It plays a key role in a variety of CNS functions, most notably long-term potentiation (LTP) and neuronal plasticity, and is regulated by several mechanisms. One such mechanism involves the amino acid glycine (1). [Pg.21]


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