GABAergic systems terminals

Abstract The CBi cannabinoid receptor is widely distributed in the central and peripheral nervous system. Within the neuron, the CBi receptor is often localised in axon terminals, and its activation leads to inhibition of transmitter release. The consequence is inhibition of neurotransmission via a presynaptic mechanism. Inhibition of glutamatergic, GABAergic, glycinergic, cholinergic, noradrenergic and serotonergic neurotransmission has been observed in many regions... 

At the same time, several other mechanisms may be activated to compensate for some of the excitatory effect, perhaps to keep the system from being hyperreactive. These mechanisms include (1) presynaptic inhibition of glutamate release from the primary afferent terminals, (2) activation of the NKl receptors on the soma/dendrite of GABAergic intemeurons to enhance GABA release, and (3) an enhanced glycine synaptic transmission via an enhanced glycine receptor function through a protein kinase C or a Ca/calmodulin dependent protein kinase 11 pathway (Fig. 2). 

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