Ionotropic glutamate receptors binding

Ibrahim HM, Hogg AJ Jr, Healy DJ, Haroutunian V, Davis KL, et al. 2000. Ionotropic glutamate receptor binding and subunit mRNA expression in thalamic nuclei in schizophrenia. Am J Psychiatry 157 1811-1823. 

Newell KA, Zavitsanou K, Huang XF. 2005. Ionotropic glutamate receptor binding in the posterior cingulate cortex in schizophrenia patients. Neuroreport 16 1363-1367. 

Arinaminpathy, Y Sansom, M. S. P, and Biggin, B. C. (2002) Molecular Dynamics simulations of the ligand binding domain of the ionotropic glutamate receptor GluR2. Biophys. J. 82,676-693. 

Ibrahim H. M., Healy D. J., Hogg A. J., Jr., and Meador-Woodruff J. H. (2000). Nucleus-specific expression of ionotropic glutamate receptor subunit mRNAs and binding sites in primate thalamus. Brain Res. Mol. Brain Res. 79 1-17. 

Fig. 1. Domain structure of ionotropic glutamate receptors (iGluRs) showing the four major components of mammalian iGluRs and the transmembrane topology. Bacterial iGluRs do not have the ATD and the C-terminal domain, and kainate binding proteins from lower vertebrates do not have the ATD. Note that SI and S2 refer to segments of the primary sequence whereas, Lobes 1 and 2 refer to protein folding units. Both Lobes 1 and 2 are made up of pordons of both SI and S2.

McFeeters, R. L., and Oswald, R. E. (2002). Structural mobility of the extracellular ligand-binding core of an ionotropic glutamate receptor. Analysis of NMR relaxation dynamics. Biochem. 41, 10472-10481. 

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