Gelling, ionotropic

A simple example of gel formation is provided by chitosan tripolyphosphate and chitosan polyphosphate gel beads the pH-responsive swelling abihty, drug-release characteristics, and morphology of the gel bead depend on polyelectrolyte complexation mechanism and the molecular weight. The chitosan beads gelled in pentasodium tripolyphosphate or polyphosphoric acid solution by ionotropic cross-hnking or interpolymer complexation, respectively. 

Typically, a binary system was selected as the base component of the recipe and the addition of polyelectrolytes to either side (core or receiving bath) was tested to evaluate the change in the capsule properties. The 33 successful multicomponent membrane systems are presented in Table 1. The components of the core material side (21 different chemical compositions) are listed in the first column, while the receiving bath components (20 different chemical compositions) are listed in the second column. With the exception of xanthan and CMC, the first polymer listed on the core side are gelling polymers which form beads with the appropriate ionotropic cation (salt). CMC can also be gelled by ions (alum), although they are considered to be non-compatible for cellular applications. The cations were tested both sequentially, usually with ionotropic cation first, and simultaneously. Walled capsules with adequate mechanical properties were often obtained through the simultaneous application of two polycations. Such a... 

Carboxymethyaltion of Gum kondagogu with monochloro-acetic acid Metformin ionotropically gelled beads Ex-vivo bio adhesion studies of CMGK beads revealed bioadhesion greater than 80% over a period of 24 h and drug release rate from the beads followed Fickian diffusion mechanism with zero-order release kinetics. [6]... 

M. Ahuja, M. Yadav, and S. Kumar, AppHcation of response surface methodology to formulation of ionotropically gelled gum cordia/gellan beads, Carbohydr. Polym., 80 (1),... 

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