Ionotropic glutamate receptors functions

McFeeters RL, Oswald RE. Emerging structural explanations of ionotropic glutamate receptor function. FASEBJ. 2004 18 428-438. 

McFeeters, R. L., and Oswald, R. E. (2004). Emerging Structural Explanations of Ionotropic Glutamate Receptor Function. FASEBJ. 18, 428-438. 

Fig. 2 Substance P induced NTS plasticity targets in the cough reflex. Plasticity targets include (1) increased intrinsic excitabUity via closure of potassium channels, activation of nonselective cation channels, opening of L-type calcium channel, and intracellular calcium release. (2) increased synaptic excitability via an increased ionotropic glutamate receptor function, a decreased GABAa receptor function. Other compensatory mechanisms may also occur, including an increased GABA release and decreased glutamate release from the afferent terminals. AP area postrema...

R 512 R, L. McFeeters and R. E. Oswald, Emerging Structural Explanations of Ionotropic Glutamate Receptor Function , FASEB J., 2004,18,428 R 513 B. Meyer and T. Peters, NMR Spectroscopy Techniques for Screening and Identifying Ligand Binding to Protein Receptors , Angew. Chem. Int. Ed., 2003,42, 864... 

Monyer H, Jonas P, Rossier J (1999) Molecular determinants controlling functional properties of AMPARs and NMDARs in the mammalian CNS, chapter 9 Ionotropic glutamate receptors in the CNS. Springer Verlag... 

The NMDA receptor is an ionotropic glutamate receptor involved in fast excitatory neurotransmission. It plays a key role in a variety of CNS functions, most notably long-term potentiation (LTP) and neuronal plasticity, and is regulated by several mechanisms. One such mechanism involves the amino acid glycine (1). 

Six functional families of ionotropic glutamate receptor subunit can be defined by structural homologies 273... 

The regulation of intracellular neuronal Ca2+ is of high functional significance. Ca2+-dependent neurotransmitter release is reduced by the Ca2+/ATPase pump (Fossier et al. 1993). Although immediate Ca2+ currents are mediated by ionotropic glutamate receptors (i.e., NMDA) in hippocampal neurons, a sizable portion of neurons show delayed Ca2+ increases from intracellular pools (Miller et al. 1996). These delayed changes were synaptically mediated and dependent upon endosomal Ca2+/ATPase. 

Molnar E, Varadi A, Mcllhinney RA, Ashcroft SJ. Identification of functional ionotropic glutamate receptor proteins in pancreatic beta-cells and in islets of Langerhans. FEBS Lett 1995 371(3) 253-7. 

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