Interleukin-1 P

Gonzales, J. R., Hermann, J. M., Boedeker, R. H., Francz, P. L, Biesalski, H. K., and Meyle, J. (2001). Concentration of interleukin-1 p and neutrophil elastase activity in gingival crevi-cular fluid during experimental gingivitis. /. Clin. Periodontol. 28,544—549. 

BOX 4.4. REDUCTION OF A DOMAIN THAT CONTRIBUTES TO AN ADVERSE (INFLAMMATORY) RESPONSE OF THE CYTOKINE INTERLEUKIN-1 P (IL-ip)... 

Caughey, G., Mantzioris, E., Gibson, R., Cleland, L., and James, M. 1996. The effect on human tumor necrosis factor a and interleukin 1 p production of diets enriched with n-3 fatty acids from vegetable oils or fish oil. Am. J. Clin. Nutr. 63, 116-122. 

Accumulation of P-amyloid proteins in the brain is one of the hallmarks of Alzheimer s disease. Dietary curcumin at low dose (160ppm) and high dose (5000ppm) significantly lowered oxidized proteins and interleukin 1-P, a pro-inflammatory cytokine... 

Ozawa H, Nakagawa S, Tagami H, Aiba S (1996) Interleukin-1 p and granulocyte-macrophage colony-stimulating factor mediate Langerhans cell maturity differently. J Invest Dermatol 106 441-445... 

Finder, J.D., Litz, J.L., Blaskovich, M.A., McGuire, T.F., Qian, Y., Hamilton, A.D., Davies, P., and Sebti, S.M. (1997). Inhibition of protein geranylgeranylation causes a superinduction of nitric-oxide synthase-2 by interleukin-1 p in vascular smooth muscle cells. /5io/ Chem 272 13484-13488. 

Daphna-lken D, Morrison AR. Interleukin-1 p induces interstitial collagenase gene expression, and protein secretion in renal mesangial cells. Am J Physiol Renal Fluid Electrolyte Physiol 1995 269 F831-F837. 

NITRERGIC STIMULANTS mimic, or cause the production and release of nitric oxide (NO), which is an important mediator that is synthesized on demand. The actions of nitric oxide are very widespread, and imbalance is likely to be involved in a number of disease states. Nitric oxide synthase (NOS) has a widespread distribution in the body, and isoforms are recognized specifically constitutive and inducible (iNOS) forms. Both forms are cytosolic, Ca /calmodulin and NADPH-dependent, and inhibited by L-arginine derivatives. Induction of iNOS is by various inflammatory cytokines, particularly those stimulated by bacterial lipopolysaccarides, including tumour necrosis factor a. interferon 7 and interleukin 1 p. Induction of iNOS only is inhibited by GLUCOCORTICOIDS. 

Chujor CS, BClein L, Lam C. Selective inhibition of interleukin-1 p gene expression in activated RAW 264,7 macrophages by interferon-gamma. Eur J Immunol 1996 26 1253-9. 

Friedlander RM, Gagliardini V, Roteilo RJ, Yuan J. Functional role of interleukin 1 p (IL-1 P) in IL-1 p-converting enzyme-mediated apoptosis. J Exp Med 1996 184 717-24. 

Law K, Weiden M, Harkin T, et al. Increased release of interleukin-1 p, mterleukin-6, and tumor necrosis factor-a by bronchoalveolar cells lavaged from involved sites in pulmonary tuberculosis. Am J Respir Crit Care Med 1996 153 799-804. 

Rodriguez C> Lacasse C, Hoang T. Interleukin-1 P suppresses apoptosis in CD34 positive bone marrow cells through activation of the type I IL-1 receptor. J Cell Physiol 1996 166 387-96. 

Tabraue, C., Penate, R.D., Gallardo, G., Hernandez, I., Quintana, J., Blanco, F.L., Reyes, J.G., Fanjul, L.F., and Ruiz De Galarreta, C.M. (1997). Induction of guanosine triphosphate-cyclohydrolase by follicle-stimulating hormone enhances interleukin-1 P-stimulated nitric oxide synthase activity in granulosa cells. Endocrinology 738 162-168. 

Hara H., Friedlander, R. M., Gagliardini, V., Ayata, C., Fink, K., Huang, Z., et al. (1997) Inhibition of Interleukin 1 p converting enzyme family proteases reduces ischemic and excitotoxic neuronal damage. Proc. Natl. Acad. Sci. USA 94, 2007-2012. 

Takeda M, Kobayashi M, Shirato I, Osaki T, Endou FI. Cisplatin-induced apoptosis of immortalized mouse proximal tubule cells is mediated by interleukin-1 p converting enzyme (ICE) family of proteases but inhibited by overexpression of Bcl-2. Arch Toxicol 1997 71 612-621. 

Tesch GH, Yang N, Yu H, tan HY Foti R, Chadban SJ, Atkins RC, Nikolic-Paterson DJ. Intrinsic renal cells are the major source of interleukin-1 p synthesis in normal and disease. Nephrol Dial Transplant 1997 12(6) 1109-1115. 

Much of what is known about PGHS-2 comes from studies on cultured fibroblasts, endothelial cells, and macrophages [7]. Typically, PGHS-2 is induced rapidly (1-3 h) and dramatically (20- to 80-fold). Platelet-derived growth factor, phorbol ester, and interleukin-ip induce PGHS-2 expression in fibroblasts and endothelial cells. Bacterial lipopolysaccharide, interleukin-1 p, and tumor necrosis factor a stimulate PGHS-2 in monocytes and macrophages. While only a limited number of tissues and cell types have... 

SCH 58450 inhibited recombinant human FPTase (IC50 = 29 pM) and was 25-fold selective over GGPTase I (IC50 = 740 pM) [130]. EP-1507-2 was also reported to inhibit interleukin-1 p converting enzyme with an IC50 value of 0.42 pM [131], however, the mechanism of inhibition was not reported. 

Maheo K, Antras-Eerry J, Morel E, Langouet S, Guillouzo A. Modulation of glutathione S-transferase subunits A2, Ml, and PI expression by interleukin-1 p in rat hepatocytes in primary culture. J Biol Chem 1997 272 16125-16132. 

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