Bronchoalveolar lavage cells

The majority of studies on sihca-induced NF-kB achvation were conducted through in vitro sihca exposure of selected cell types. Only a few studies have examined the effect of silica on NF-kB in vivo. Using bronchoalveolar lavage cells from rats exposed to sihca. Porter et al. demonstrated that NF-kB activahon in the silica-exposed rats increased progressively throughout the 116-day sihca inhalation period. The expression... 

Rose RM, Krivine A, Pinkston P, Gillis JM, Huang A, Hammer SM. Frequent identification of HIV-1 DNA in bronchoalveolar lavage cells obtained from individuals with the acquired immunodeficiency syndrome. Am Rev Respir Dis 1991 143 850-854. 

Bronchoalveolar lavage cells (lx 10 ) suspended in Dulbecco s phosphate buffered saline (0.5 ml) containing 5,5-dimethyl-l-pyrroline-1-oxide (DMPO 100 mM) in duplicate samples, one with and one without superoxide dismutase (500 imits/ml) by electron paramagnetic resonance measurements recorded superoxide anion generation at sites of antigen challenge (Sanders et al. 1995). 

In a mouse model of inflammatory lung reaction induced by intratracheal instillation of silica, the levels of IL-10 protein both in cells obtained after bronchoalveolar lavage and in lung tissue homogenates were significantly increased when compared with controls (Huaux et al. 1998). After in vitro li-popolysaccharide stimulation (1 ig/ml), bronchoalveolar lavage cells obtained from silica-treated animals produced significantly more IL-10 protein and mRNA than cells obtained from control animals. 

The early acute pulmonary response of Mstar rats exposed nose-only to respirable polymeric diphenyl-methane 4,4 -diisocyanate aerosol for 6 h were bronchoalveolar lavage cells markedly loaded with phosphatidylcholine (Pauluhn 2000). Bronchoalveolar lavage cells from rats repeatedly exposed to 12.9 mg polymeric diphenyl-methane 4,4 -diisocyanate m" air (6 h/day, 5 days/week for 14 days exposure was from days 0-17 followed by a post-exposure period to day 35) increased in number and phospholipid content significantly in a time-dependent marmer and returned to almost... 

Treatment of asbestosis and idiopathic pulmonary fibrosis with colchicine (0.6 mg orally for 12 weeks) resulted in declines in dyspnoea index, selective improvement in several high-resolution computed tomography scans, but no statistically significant changes in bronchoalveolar lavage cells, cytokines, fibronectin, or hydroxyproline (Addriz-zo-Harris et al. 2002). However, there was a decline in hydroxyproline in the bronchoalveolar lavage fluid in 8 of 10 patients. 

Branley HM, Wells AU, du Bois RM, Jones HA. Quantification of the in vitro binding of 3H-PK11195 to bronchoalveolar lavage cells in patients with interstitial lung disease compared to normal non-smoking healthy individuals. Unpubhshed. 

Ziegenhagen MW, Schrum S, Zissel G, et al. Increased expression of pro-inflammatory chemokines in bronchoalveolar lavage cells of patients with progressing idiopathic pulmonary fibrosis and sarcoidosis. J Investig Med 1998 46(5) 223-231. 

Holter JF, Park UK, Sjoerdsma KW, et al. Nonviable autologous bronchoalveolar lavage cell preparations induce intradermal epitheloid cell granulomas in sarcoidosis patients. Am Rev Respir Dis 1992 145 864-871. 

Zissel G, Baumer I, Schlaak M, et al. In vitro release of interleukin-15 by bronchoalveolar lavage cells and peripheral blood mononuclear cells from patients with different lung diseases. Fur Cytokine Netw 2000 11(1) 105-112. 

Muller-Quemheim J, Pfeifer S, Kienast K, et al. Spontaneous interleukin 2 release of bronchoalveolar lavage cells in sarcoidosis is a codeterminator of prognosis. Lung 1996 174(4) 243-253. 

Oshima M, Maeda A, Ishioka S, et al. Expression of C-C chemokines in bronchoalveolar lavage cells from patients with granulomatous limg diseases. Limg 1999 177(4) 229-240. 

Sato H, Silveira L, FingerUn T, et al. TNF polymorphism and bronchoalveolar lavage cell TNF-alpha levels in chronic beryllium disease and beryllium sensitization. J Allergy Clin Immunol 2007 119(3) 687-696. 

Wells AU, Lorimer S, Majumdar S, et al. Fibrosing alveolitis in systemic sclerosis increase in memory T-cells in lung interstitium. Eur Respir J 1995 8 266-271. Luzina IG, Atamas SP, Wise R, et al. Gene expression in bronchoalveolar lavage cells from scleroderma patients. Am J Respir Cell Mol Biol 2002 26 549-557. Bolster MB, Ludwicka A, Sutherland SE, et al. Cytokine concentrations in bronchoalveolar lavage fluid of patients with systemic sclerosis. Arthritis Rheum 1997 40 743-751. 

Nagai 8, Aung H, Tanaka 8, et al. Bronchoalveolar lavage cell findings in patients with BOOP and related diseases. Chest 1992 102 328-378. 

Gariepy L, Cormier Y, Laviolette M et al (1989) Predictive value of bronchoalveolar lavage cells and serum precip-itins in asymptomatic dairy farmers. Am Rev Respir Dis 140 1386-1389... 

Robinson D, Hamid Q, Ying S, et al. Prednisolone treatment in asthma is associated with modulation of bronchoalveolar lavage cell interleukin, interleukin-5, and interferon-gamma cytokine gene expression. Am Rev Respir Dis 1993 148 401— 406. 

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