Interleukin-4-alpha receptor

Stemmier S, Arinir U, Klein W, et al. Association of interleukin-8 receptor alpha polymorphisms with chronic obstructive pulmonary disease and asthma. Genes Immun 2005 6(3) 225-230. 

Uematsu, S., et al., Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon- alpha induction, J. Exp. Med. 201, 6, 915, 2005. 

Clinical pharmacology Basiliximab is a chimeric (mouse/human) interleukin-2 receptor antagonist. It is directed against the interleukin-2 receptor-alpha chain (CD25) on activated T-lymphocytes, and is a potent inhibitor of interleukin-2-mediated activation of lymphocytes, a critical pathway in the cellular immune response involved in allograft rejection. Another anti-CD25 monoclonal antibody, dacUzumab (Zenapax), has the same indication as basiliximab. 

Class Immunosuppressive chimeric monoclonal antibody, specifically binds to and blocks the interleukin-2 receptor alpha chain on the surface of activated T- lymphocytes... 

Tavernier J, Devos R, Comelis S, Tuypens T, et al. 1991. A human high affinity interleukin-5 receptor (IL5R) is composed of an IL5-specific alpha chain and a beta chain shared with the receptor for GM-CSF. Cell. 66 1175-1184. 

Przepiorka D, Keman NA, Ipppoliti C, Papandopoulas EB, et al. 2000. Dachzumab, a humanized anti-interleukin-2 receptor alpha chain antibody, for the treatment of acute graft-versus-host disease Blood. 2000 83-89. 

Hershey GK, Friedrich MF, Esswein LA, Thomas ML, Chatila TA. The association of atopy with a gain-of-function mutation in the alpha subunit of the interleukin-4 receptor. N Engl J Med 1997 337(24) 1720-1725. 

Rao BM, Girvin AT, Ciardelli T, Lauffenburger DA, Wittrup KD. Interleukin-2 mutants with enhanced alpha-receptor subunit binding affinity. Protein Eng 2003 16 1081-7. 

Kuhn DJ, Dou QP. The role of interleukin-2 receptor alpha in cancer. Frontiers Biosci 2005 10 1462-74. 

Boulanger, M. J., Chow, D. C., Brevnova, E. E., and Garcia, K. C. (2003b). Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gpl30 complex. Science 300, 2101-2104. 

Hage, T., Sebald, W., and Reinemer, P. (1999). Crystal structure of the interleukin-4/receptor alpha chain complex reveals a mosaic binding interface. Cell 97, 271-281. 

Li, H., and Nicholas, J. (2002). Identification of amino acid residues of gpl30 signal transducer and gp80 alpha receptor subunit that are involved in ligand binding and signaling by human herpesvirus 8-encoded interleukin-6. / Virol. 76, 5627-5636. 

Shen, B. J., Hage, T., and Sebald, W. (1996). Global and local determinants for the kinetics of interleukinA /interleukin-4 receptor alpha chain interaction. A biosensor study employing recombinant interleukin-4-binding protein. Eur. J. Biochem. 240(1), 252-261. 

CD123 interleukin 3 receptor, alpha (low affinity). The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for... 

Macdonald D, Jiang YZ, Swirsky D, Vulliamy T, MorUla R, Bungey J, Barrett AJ. Acute myeloid leukaemia relapsing following interleukin-2 treatment expresses the alpha chain of the interleukin-2 receptor. Br J Haematol 1991 77(l) 43-9. 

Basiliximab is a chimeric (human/mouse) anti-inter-leukin-2 receptor monoclonal antibody used in the prophylaxis of acute renal transplant rejection. It acts by binding the alpha chain of interleukin-2 receptors on activated T lymphocytes. Initially positive results in phase III trials have not been generally confirmed (1,2). 

Ober C, Leavitt SA, Tsalenko A, et al Variation in the interleukin 4-receptor alpha gene confers susceptibility to asthma and atopy in ethnically diverse populations. Am J Hum Genet 2000 66 517-526. (Ill)... 

Daaka Y, Zhu W, Friedman H, Klein TW (1997) Induction of interleukin-2 receptor alpha gene by delta-9-tetrahydrocannabinol is mediated by nuclear factor kappaB and CBI cannabinoid receptor. DNA Cell Biol 16 301-309... 

West, D. A., James, N. H., Cosulich, S. C., Holden, P. R., Brindle, R., Rolfe, M., and Roberts, R. A. (1999). Role for tumor necrosis factor alpha receptor 1 and interleukin-1 receptor in the suppression of mouse hepatocyte apoptosis by the peroxisome proliferator nafenopin. Hepatology 30,1417-1424. 

Rickert M, Wang X, Boulanger MJ et al (2005) The structure of interleukin-2 complexed with its alpha receptor. Science 308 1477-1480... 

Lowenthal, J. W., Ballard, D. W., Bohniein, E., and Greene, W. C. Tumor necrosis factor alpha induces proteins that bind specifically to kappa B-like enhancer elements and regulate interleukin-2 receptor alpha-chain gene expression in primary human T lymphocytes. Proc. Natl. Acad Sci. U.SA. 86, 2331-2335 (1989). 

Perkins, J. D., Munn, S. R., Barr, D., Ferguson, D. C., and Carpenter, H. A. Evidence that the soluble interleukin-2 receptor level may determine the optimal time for cystoscopically-di-rected biopsy in pancreaticoduodenal allograft recipients. Transplantation 49,363-366 (1990). Pessara, U., and Koch, N. Tumor necrosis factor alpha regulates expression of the major histocompatibility complex class 11-associated invariant chain by binding of an NF-kappa B-like factor to a promoter element. Mol. Cell Biol. 10, 4146-4154 (1990). 

M. Control of IL-2 receptor-alpha expression by lL-1, tumor necrosis factor, and lL-2. Complex regulation via elements in the 5 flanking region. J. Immunol. 145, 3340-3347 (1990). Plaetinck, G., Van der Heyden, J., Tavernier, J., Fache, I., Tuypens, T., Fischkoff, S., Fiers, W., and Devos, R. Characterization of interleukin-5 receptors on eosinophilic sublines from human promyelocytic leukemia (HL-60) cells. J. Exp. Med. 172, 683-691 (1990). 

Tl 1. Toledano, M. B., Roman, D. G., Halden, N. F., Lin, B. B., and Leonard, W. J. The same target sequences are differentially important for activation of the interleukin-2 receptor alpha-chain gene in two distinct T-cell lines. Proc. Natl. Acad. Sci. U.SA. 87, 1830-1834 (1990). 

Moore KW, de Waal Malefyt R, Coffman RL, O Garra A (2001) Interleukin-10 and the interleukin-10 receptor. Annu Rev Immunol 19 683-765 Morio LA, Chiu H, Sprowles KA, Zhou P, Heck DE, Gordrai MK, Laskin DL (2001) Distinct roles of tumor necrosis factor-alpha and nitric oxide in acute Uvct injury induced by carbon tetrachloride in mice. Toxicol Appl Pharmacol 172 44—51 Murata H, Shimizu Y, Okada K, Higuchi K, Watanabc A (2003) Detection and analysis of intracytoplasmic cytokines in peripheral blood mononuclear cells in patioits with drag-induced liver injury. J Hepatol 38 573-582... 

Fig. 4 Mechanisms determinants in repair of acetaminophen-induced hepatic necrosis. VEGF Vascular endothelial growth factor, TNF-a tumor necrosis factor alpha, TNRl tumor necrosis factor alpha receptor 1, MIP-2 macrophage inflammatory protein, IP-10 Interferon-y-inducible protein, IL-6 Interleukin-6...

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