Receptors alpha subunit

Wiley, L.J., Weiss, A.S., Sangster, N.C. and Li, Q. (1996) Cloning and sequence analysis of the candidate nicotinic acetylcholine receptor alpha subunit gene tar-1 from Trichostrongylus colubriformis. Gene 182,97—100. 

Smith, G. B. and Olsen, R. W. (1994) Identification of a [3H]muscimol photoaffinity substrate in the bovine gamma-aminobutyric acidA receptor alpha subunit../. Biol. Chem. 269, 20380-20387. 

Tsouloufis, T., A. Mamalaki, M. Remoundos, and S.J. Tzartos (2000). Reconstitution of conformationally dependent epitopes on the N-terminal extracellular domain of the human muscle acetylcholine receptor alpha subunit expressed in Escherichia colt implications for myasthenia gravis therapeutic approaches. Int Immunol 12(9) 1255-1265. 

Fig. 5 Dose-response curves for discriminative stimulus effects of nicotine in wild-type (filled circle) and knockout (open circle) mice trained with nicotine (0.8mg kg ), (a) shows results for 32 null mutant and control mice from Shoaib et al, (2002) whereas (b) shows corresponding results for a nuU mutants and their wild-type controls from Stolerman et al, 2004, Discriminative responding on the drug-appropriate lever is expressed as a percentage of the total numbers of responses on both levers. All data shown as means s,e,m, from 5-min extinction tests (n = 8-12). Figure 4a was published in Shoaib et al. (2002) The role of nicotinic receptor beta-2 subunits in nicotine discrimination and conditioned taste aversion. Copyright Elsevier Fig, 4b was published in Stolerman et al, (2004), The role of nicotinic receptor alpha subunits in nicotine discrimination. Copyright Elsevier...

Sibille E, Pavlides C, Benke D, Toth M. Genetic inactivation of the serotonin(lA) receptor in mice results in downregulation of major GABA(A) receptor alpha subunits, reduction of GABA(A) receptor binding, and benzodiazepine-resistant anxiety. J Neurosci 2000 20 2758-2765. 

Robertson MW, Phage and Escherichia coli expression of the human high affinity immunoglobulin E receptor alpha-subunit ectodomain, Domain localization of the IgE-binding site, J. Biol. Chem., 268 12736-12743, 1993. 

Rao BM, Driver I, Lauffenburger DA, Wittrup KD. Interleukin 2 (IL-2) variants engineered for increased IL-2 receptor alpha-subunit affinity exhibit increased potency arising from a cell surface ligand reservoir effect. Mol Pharmacol 2004 66 864-9. 

Wang PY, Slaughter MM (2005) Effects of GABA Receptor Antagonists on Retinal Glycine Receptors and on Homomeric Glycine Receptor Alpha Subunits. J Neurophysiol 93 3120... 

Suzuki S, ARGRAVES WS, ARAI H, LANGUINO LF, PIERSCHBACHER MD, RUOSLATHI E. Aminoadd sequence of the vitronectin receptor alpha subunit and comparative expressi< of adhesion recqRor mRNAs. J BiolChem262 14050-14058,1987. 

The recent discovery that the mutation of (figure 4) affects the desensitization rate of the 5-HT3 receptor expressed in oocytes [102] is in favor of such a hypothesis, since similar results have been reported for the mutation of the corresponding residue in the nicotinic receptor alpha subunit [116], Interestingly, some point mutations in this Mil domain have also been shown to be associated with modifications in calcium permeability [122], which may explain the reported differences in its permeability for the 5-HTa receptor [95,97,98,102]. 

T., Bennett D., Sokolski T, McNulty D., Rosenberg M., and Chaiken 1.1995. Binding interactions of human interleukin 5 with its receptor alpha subunit. Large scale production structural, and functional studies of Drosophila-expressed recombinant proteins. /. Biol. Chem. 270 9459-9471. 

Integrins themselves are found on nearly all cells and mediate several physiological responses, such as cell-cell and cell-matrix interactions. Three families of integrins, each family with a common beta subunit in combination with distinct alpha subunits, have been recognized. The beta 1 family, also called very late lymphocyte-activation antigen or VLA, has receptors mediating extracellular matrix interactions with molecules such as collagen, laminin, and fibronectin. Naturally, platelets contain many of the receptors of the beta 1 family. 

Unwin, N., Projection structure of the nicotinic acetylcholine receptor distinct conformations of the alpha subunits, J. Mol. Biol., 257, 586-596, 1996. 

Sato, K., Zhang, J. H., Saika, T. et al. (1991). Localization of glycine receptor alpha 1 subunit mRNA-containing neurons in the rat brain an analysis using in situ hybridization histochemistry. Neuroscience 43, 381-95. 

Le Novere N, Zoli M, Changeux JP. Neuronal nicotinic receptor alpha 6 subunit mRNA is selectively concentrated in catecholaminergic nuclei of the rat brain. Eur J Neurosci 1996 8(ll) 2428-2439. Picciotto MR et al. Abnormal avoidance learning in mice lacking functional high-affinity nicotine receptor in the brain. Nature 1995 374(6517) 65-67. 

Pascual, J.M., and Karlin, A. (1998) State-dependent accessibility and electrostatic potential in the channel of the acetylcholine receptor. Inferences from rates of reaction of thiosulfonates with substituted cysteines in the M2 segment of the alpha subunit./. Gen Physiol. 111(6), 717-739. 

Hiemke, C. et al., Expression of alpha subunit genes of nicotinic acetylcholine receptors in human lymphocytes, Neurosci. Lett., 214,171, 1996. 

Amin, J., Brooks-Kayal, A., and Weiss, D. S. (1997) Two tyrosine residues on the alpha subunit are crucial for benzodiazepine binding and allosteric modulation of gamma-aminobutyric acidA receptors. Mol. Pharmacol. 51, 833-841. 

Duncalfe, L. L Carpenter, M. R Smillie, L. B Martin, I. L and Dunn, S. M. (1996) The major site of photoaffinity labeling of the gamma-aminobutyric acid type A receptor by [3H]flunitrazepam is histidine 102 of the alpha subunit../. Biol. Chem. 271,9209-9214. 

Wisden, W Herb, A., Wieland, H., Keinanen, K Liiddens, H and Seeburg, P. H. (1991) Cloning, pharmacological characteristics and expression pattern of the rat GABAA receptor alpha 4 subunit. FEBS Lett. 289,227-230. 

Verdoom, T. A. (1994) Formation of heteromeric gamma-aminobutyric acid type A receptors containing two different alpha subunits. Mol. Pharmacol. 45,475 480. 

Steinlein OK, MuUey JC, Propping P, Wallace RH, Phillips HA, Sutherland GR, Scheffer IE, Berkovic SF (1995) A missense mutation in the neuronal nicotinic acetylcholine receptor alpha 4 subunit is associated with autosomal dominant nocturnal frontal lobe epilepsy. Nat Genet 11 201-203... 

Kauer JA, Malenka RC (2007) Synaptic plasticity and addiction. Nat Rev Neurosci 8 844-858 Kawai H, Berg DK (2001) Nicotinic acetylcholine receptors containing alpha subunits on rat cortical neurons do not undergo long-lasting inactivation even when up-regulated by chronic nicotine exposure. J Neurochem 78 1367-1378... 

Zaleplon binds selectively to the brain omega- receptor situated on the alpha subunit of the GABA receptor complex and potentiates... 

Pharmacology Daclizumab is an immunosuppressive, humanized IgGI monoclonal antibody produced by recombinant DNA technology that binds specifically to the alpha subunit (Tac subunit) of the human high-affinity interleukin-2 (IL-2) receptor that is expressed on the surface of activated lymphocytes. Daclizumab is a composite of human (90%) and murine (10%) antibody sequences. 

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