Humanized mice

Monoclonal antibodies (mAh) are molecules that recognize and bind a specific foreign substance called an antigen. They are produced from a single clone of B lymphocytes. Conventionally, mouse mAh have been generated for experimental and diagnostic use. Techniques have been developed to humanize mouse mAh to facilitate their therapeutic use in humans. It is also now possible to make mAh which are fully human. [Pg.600]

CN immunoglobulin G (human-mouse monoclonal c7E3 clone p7E3VHhCy4 Fab fragment antihuman... [Pg.4]

In addition, stndies evaluating interferon alpha/beta and interlenkin-16 expression have shown snbstantial antiviral effects against HlV-1 in vitro and in a humanized mouse model (Cremer et al. 2000 Lanret et al. 1994 Sanhadji et al. 1997 Zhou etal. 1997). [Pg.284]

Cetuximab is a human/mouse antibody that binds to the epidermal growth factor receptor to block its stimulation. The pharmacokinetics of cetuximab demonstrate a volume of distribution that approximates the vascular space and a terminal half-life of 70 to 100 hours. Cetuximab has shown clinical activity in the treatment of colorectal cancer. An acnelike rash may appear on the face and upper torso 1 to 3 weeks after the start of therapy. Other side effects include hypersensitivity reactions, interstitial lung disease, fever, malaise, diarrhea, abdominal pain, and nausea and vomiting. [Pg.1294]

Trastuzumab (Herceptin) -humanized mouse monoclonal antibody directed against HER-2/new receptor -fevers, chills, nausea, vomiting, headache during administration -cardiotoxicity (the FDA has not approved concurrent use with doxorubicin)... [Pg.180]

Ando-Akatsuka Y, Saitou M, Hirase T, Kishi M, Sakakibara A, Itoh M, Yonemura S, Furuse M, and Tsukita S [1996] Interspecies diversity of the occludin sequence cDNA cloning of human, mouse, dog and ratkangaroo homologues. J Cell Biol 133 43 17... [Pg.362]

K. Yeowell O Connell, W. Pauwels, M. Seven, Z. L. Jin, M. R. Walker, S. M. Rappa-port, H. Veulemans, Comparison of Styrene-7,8-oxide Adducts Formed via Reaction with Cysteine, N-Terminal Valine and Carboxylic Acid Residues in Human, Mouse and Rat Hemoglobin , Chem.-Biol. Interact. 1997, 106, 67 - 85. [Pg.676]

A database search reveals that YPClp and YDClp are not homologous to any proteins with known functions, but are homologous to putative proteins from Arabidoposis, C. elegans, peptides deduced from EST sequences of human, mouse, pig, zebra fish, and human genomic sequences. A human homologue has been identified and its cDNA has been cloned. Preliminary results show that this human homologue is also an alkaline ceramidase that selectively hydrolyzes phytoCer. [Pg.195]

Corchero J, Granvil CP, Akiyama TE, Hayhurst GP, Pimprale S, et al. 2001. The CYP2D6 humanized mouse effect of the human CYP2D6 transgene and HNF4alpha on the disposition of debrisoquine in the mouse. Mol Pharmacol 60 1260-1267. [Pg.82]

Miksys SF, Cheung C, Gonzalez FJ, Tyndale RF. 2005. Human CYP2D6 and mouse CYP2DS organ distribution in a humanized mouse model. Drug Metab Dispos 33 1495-1502. [Pg.87]

Fig. 3. Sequence alignment of C-terminal regions of H2A.X homologues from human, mouse, S. cerevisiae and S. pombi, and human H2A.2. In yeast, the major H2A variants contain the SQ motif (underlined) that is characteristic of H2A.X. Mammalian H2A.X and H2A.2 are nearly identical in sequence in the regions not shown. Sequences human H2A.X, GI 106266 mouse H2A.X, GI 51142 S. cerevisiae H2A.1, GI 6320431 S. pombiYtlAa, GI 19075680 human H2A.2, GI 121970.

Colon (freshly isolated colonic cells from human, mouse, rat) Colon (epithelial cells in rat tissue sections)... [Pg.53]

Interspecies differences (animal-to-human) mouse, a default value of 7 X 3 rat, a default value of 4 X 3 rabbit, a default value of 2.4 X 3 dog, a default value of 1.4 X 3. The first factor for each species is a calculated adjustment factor, allowing for differences in basal metabolic rate (proportional to the 0.75th power of body weight). The second factor of 3 is the assessment factor applied for remaining uncertainties (Section 5.3.3), for which the default value is 3. For local skin and respiratory tract effects, the assessment factor is 3, as adjustment for differences in body size is inappropriate. [Pg.221]

ZMAL also for HDACs from various species (maize, human, mouse) Complicated substrate... [Pg.103]

Testing for human-mouse antibody titers is strongly recommended a titer greater than or equal to 1 1000 is a contraindication for use. [Pg.1980]

Immunoglobulin Gl, anti-(human interleukin 2 receptor) (human-mouse monoclonal clone... [Pg.504]

H4 gamwal-chain), disulfide with human-mouse monoclonal clone 1H4 light chain, dimer [CAS]... [Pg.505]

Immunoglobulin Gi(human-mouse monoclonal clone 1H4 gamma-chain anti-human antigen Tac), disulfide with human-mouse monoclonal clone 1H4 light chain, dimer [SY] Immunoglobulin Gi(human-mouse monoclonal clone 1H4 gamma-chain antihuman interleukin 2 receptor), disulfide with human-mouse monoclonal clone 1H4 light chain, dimer [SY]... [Pg.505]

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