Interferon-y receptor

Jouanguy, E., Lanhamedi-Cherradi, S., Altare, E, etal, Partial interferon-y receptor I deficiency in a child with tuberculoid bacillus Calmette-Guerin infection and a sibling with clinical tuberculosis. J. Clin. Invest. 100, 2658-2664 (1997). 

Takei Y, Sims TN, Urmson J, Halloran PF. Central role for interferon y receptor in the regulation of renal MHC expression. J Am Soc Nephrol 2000 11(2) 250-261. 

Novick, D. (1987). The Human Interferon-y-receptor Purification, Characterization, and Preparation of Antibodies, Biol. Chem. 262 8483-8487. 

Myxomatosis is associated with general immunosuppression of the host and thus MV was a prime candidate to encode immune evasion molecules. Initial work identified the MV M-T7 gene encoding a 37 kDa glycoprotein that is abundantly secreted from infected cells. The M-T7 ORF showed significant similarity to the extracellular binding domain of human and mouse interferon-y receptors (IFN-yRs), and was shown to bind to and inhibit the biological activity of rabbit IFN-y in a species specific manner. ... 

Kotenko SV, Izotova LS, Pollack BP, Mariano TM, Donnelly RJ, Muthukumaran G, Cook JR, Garotta G, Silvennoinen O, Ihle JN (1995) Interaction between the components of the interferon-y receptor complex. J Biol Chem 270 20915-20921... 

MYXV M-T7 is a secreted 37-kDa glycoprotein with sequence similarity to the interferon y receptor (IFN-yR) that binds to and inhibits the biological activity of... 

Inflammatory cytokines have been implicated in the pathophysiology of HF.9 Several proinflammatory (e.g., tumor necrosis factor-a [TNF-a], interleukin-1, interleukin-6, and interferon-y) and anti-inflammatory cytokines (e.g., interleukin-10) are overexpressed in the failing heart. The most is known about TNF-a, a pleiotrophic cytokine that acts as a negative inotrope, stimulates cardiac cell apoptosis, uncouples 3-adrenergic receptors from adenylyl cyclase, and is related to cardiac cachexia. The exact role of cytokines and inflammation in HF pathophysiology continues to be studied. 

Based upon recent controlled studies, there is considerable evidence that opioids such as morphine induce substantial effects on immune status. For example, it has been shown that morphine administration is associated with alterations in a number of immune parameters, such as natural-killer cell activity [12,13], proliferation of lymphocytes, [13, 14] antibody production [15,16], and the production of interferon [17]. Studies in our laboratory have shown that acute morphine treatment in rats suppresses splenic lymphocyte proliferative responses to both T- and B-cell mitogens, splenic natural-killer cell activity, blood lymphocyte mitogenic responsiveness to T-cell mitogens, and the in vitro production of the cytokines interleukin-2 and interferon-y [18-22], Furthermore, the immune alterations induced by morphine are dose-dependent and antagonized by the opioid-receptor antagonist, naltrexone (e.g., [22]). 

Diamantstein, T. et al, Reversal by interferon-y of inhibition of delayed-type hypersensitivity induction by anti-CD4 or anti-interleukin 2 receptor (CD25) monoclonal antibodies. Evidence for the physiological role of the CD4+Thl+ subset in mice. Eur. J. Immunol., 181, 2101, 1988. 

Huizinga, T. W. J., Van Der Schoot, C. E., Roos, D., Weening, R. S. (1991). Induction of neutrophil Fc-y receptor 1 expression can be used as a marker for biologic activity of recombinant interferon-yin vivo. Blood 77,2088-90. 

Seymour BW. Gershwin LJ. Coffman RL Aerosol-induced immunoglobulin-E unresponsiveness to ovalbumin does not require CDS 4- or T-cell receptor-y/8-H T cells or interferon-y in a murine model of allergen sensitization. 1 Exp Med 1998 187 721-731. 

Young, H. Hardy, K. (1995). Role of interferon-y in immune cell regulation. J. Leukocyte Biol. 58, 373-379. Zavyalov, V. Zavyalova, G. (1997). Interferons ajp and their receptors — place in the hierarchy of cytokines. APMIS 105(3), 161-186. 

Inhibitory Smads Smad 6 and Smad 7 function as inhibitors of TGPp signaling. They bind to type I receptors and interfere with phosphorylation of the pathway-restricted Smads. These Smad proteins may be used to modulate and weaken the TGPp receptor. Such transmodulation has been described for the interferon y pathway. Activation of the IFNy pathway leads to increased transcription of Smad 7, which diminishes signal conduction in the TGPp pathway (Ulloa et al., 1999). 

Jarpe MA, Johnson HM. Stable conformation of IFN-y receptor binding peptide in aqueous solution is required for IFN-y antagonist activity. J Interferon Res 1993 13 99. 

Chang, Y. and Prud homme, G.J. (1999) Intramuscular administration of expression plasmids encoding interferon-7 receptor/IgGl or IL-4/IgGl chimeric proteins protects from autoimmunity. J. Gene Med., 1, 415-423. 

Although T cells can be divided into two populations (helper/inducer and cytotoxic/suppressor) based on CD4 and CD8 expression, T cells can also be divided into two populations based on the structure of the antigen receptor complex, either alp, or yIS, associated with the CD3 antigen (DIO). The yIS T cells represent approximately 5% of all T cells, lack expression of CD5, CD4, and often CD8, are thought to be associated with a more primitive type of immune response, and are usually found in the splenic red pulp and epithelial sites (A15, C26, T6). The alj3 T cells usually express all four pan-T cell antigens (CD2, CD3, CD5, and CD7) and either CD4 or CD8. The CD4-positive cells can be further divided based on cytokine secretion Thl cells, which secrete interleukin-2 (IL-2) and interferon y and help macrophages and other T cells, and Th2 cells, which secrete IL-4, IL-5, IL-6, and IL-10 and help B cells in antibody production (DIO, Dll). 

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