Lymphocyt splenic

Catovsky D, Matutes E. Splenic lymphoma with circulating villous lymphocytes/splenic marginal-zone lymphoma. Semin He-matol. 1999 36(2) 148-154. 

Diethjidithiocarbamate [20624-25-3] (DDC) is both an inhibitor of SOD and a thiol, and exerts both radiosensitizing and radioprotective properties in mice, depending on factors such as the time of its adniinistration relative to irradiation. For neutrons, DDC shows only protective effects (141). DDC (1 mg/g ip) given 30 min before 15 Gy (1500 rad) also protects mouse jejunal crypt ceUs and reduces the frequency of micronuclei in splenic lymphocytes (134). 

Splenic marginal zone B-cell lymphoma ( villous lymphocytes)... 

Ladies, G.S., et al., Phase two of an interlaboratory evaluation of the quantification of rat splenic lymphocyte subtypes using immunofluorescent staining and flow cytometry, Toxicol. Methods, 8, 87, 1998. 

Based upon recent controlled studies, there is considerable evidence that opioids such as morphine induce substantial effects on immune status. For example, it has been shown that morphine administration is associated with alterations in a number of immune parameters, such as natural-killer cell activity [12,13], proliferation of lymphocytes, [13, 14] antibody production [15,16], and the production of interferon [17]. Studies in our laboratory have shown that acute morphine treatment in rats suppresses splenic lymphocyte proliferative responses to both T- and B-cell mitogens, splenic natural-killer cell activity, blood lymphocyte mitogenic responsiveness to T-cell mitogens, and the in vitro production of the cytokines interleukin-2 and interferon-y [18-22], Furthermore, the immune alterations induced by morphine are dose-dependent and antagonized by the opioid-receptor antagonist, naltrexone (e.g., [22]). 

Fecho, K. et al., Macrophage-derived nitric oxide is involved in the depressed Con A-respon-siveness of splenic lymphocytes from rats administered morphine in-vivo, J. Immunol., 152, 5845, 1994. 

Rat F344 females Embryo-fetal Yes TIL-4 4-IFN-y splenic lymphocytes... 

Yellen, A J., et al. Signaling through surface IgM in tolerance-susceptible immature murine B lymphocytes. Developmentally regulated differences in transmembrane signaling in splenic B cells from adult and neonatal mice, J Immunol., 146, 1446, 1991. 

Felten, S.Y. and Olschowka, J., Noradrenergic sympathetic innervation of the spleen II. Tyrosine hydroxylase (TH)- positive nerve terminals from synaptic-like contacts on lymphocytes in the splenic white pulp, J. Neurosci. Res., 18, 37,1987. 

Nagasawa. Effect of coffee cherry on the CAl 60 activation of splenic lymphocytes in mice. Anticancer Res 1997 17(2A) ... 

A well-known effect of LPS in mice is mitogenicity to B lymphocytes. Lipid A from P. gingivalis is shown to be mitogenic in vitro even to splenic B cells from LPS-unresponsive C3H/HeJ mice [31]. The lipid A ONO-4007 is mitogenic to spleen cells from BALB/c mice [135], The role of antibodies in tumor regression has solely been documented in the... 

In rat liver, 1,2-dimethylhydrazine had no consistent effect on the relative focal volume of y-glutamyltranspeptidase-positive preneoplastic foci (Denda et al., 1988). Locniskar et al. (1985) treated Brown-Norway and Fischer rats with 150 mg/kg bw 1,2-dimethylhydrazine by gavage five times over a three-week period. Five months after the final treatment, isolated splenic, colonic intraperithelial lymphocytes and lamina propria lymphocytes from the Brown-Norway strain exhibited low natural killer cell activity and reduced splenic T-lymphocyte proliferation in response to autologous non-T lymphocytes. Furthermore, colonic lamina propria lymphocyte proliferation was low, and Brown-Norway rats had a low incidence of 1,2-dimethylhydrazine-induced colonic neoplasms (7%) in comparison with Fischer rats, which had more effective splenic and colonic intraperithelial lymphocyte natural killer cell activity, enhanced splenic autologous mixed lymphocyte response, enhanced colonic lamina propria lymphocyte proliferation and a higher incidence of colon tumours (20%). 

Locniskar, M., Nauss, K.M., Kauffman, P. Newbeme, PM. (1985) Comparison of immune status and 1,2-dimethylhydrazine induced tumorigenesis in Brown-Norway and Fischer rats. Emphasis on splenic and colonic lymphocyte function. Cancer Lett., 25, 311-323... 

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