TRAIL-induced apoptosis

Zhou J, Lu GD, Ong CS, Ong CN, Shen HM. (2008) Andrographolide sensitizes cancer cells to TRAIL-induced apoptosis via p53-mediated death receptor 4 up-regulation. Mol Cancer Ther 1 2170-2180. 

Apoptosis can be induced or prevented through different pathways (TNFa-induced, Fas-induced, TRAIL-induced). In lymphokine-activated killer cells Fas-mediated cytotoxicity could be dissociated from perforin-mediated cytotoxicity by their different requirement of TPA-sensitive PKC... 

Deeb DD, Jiang H, Gao X, Divine G, Dulchavsky SA, Gautam SC. 2005. Chemo-sensitization of hormone-refractory prostate cancer cells by curcumin to TRAIL-induced apoptosis. J Exp Ther Oncol 5 81-91. 

Jung EM, Lim JH, Lee TJ, Park JW, Choi KS, Kwon TK. 2005. Curcumin sensitizes tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis through reactive oxygen species-mediated upregulation of death receptor 5 (DR5). 

Wahl H, Tan L, Griffith K, Choi M, Liu JR. 2007. Curcumin enhances Apo2L/TRAIL-induced apoptosis in chemoresistant ovarian cancer cells. Gynecol Oncol 105 104-112. 

Aza-Blanc, P. et al. 2003. Identification of modulators of TRAIL-induced apoptosis via RNAi-based phenotypic screening. Mol. Cell 12, 627-637. 

Long, C.K.L. Lam, W.S. Chiu, L.C.M. Ooi, V.E.C. Sun, S.S.M. Wong, Y.-S. 2009. A rice bran polyphenol, eyeloartenyl ferulate, elicits apoptosis in human colorectal adenocarcinoma SW480 and sensitizes metastatic SW620 cells to TRAIL-induced apoptosis. Biochem. Pharmacol. 77 1487-1496. 

Danial NN, Korsmeyer SJ (2004) CeU death critical control points. CeU 116 205-219 Denault JB, Eckelman BP, Shin H, Pop C, Salvesen GS (2007) Caspase-3 attenuates XIAP-mediated inhibition of caspase-9. Biochem J 405(1) 11-19 Deng Y, Lin Y, Wu X (2002) TRAIL-induced apoptosis requires Bax-dependent mitochondrial release of Smac/DIABLO. Genes Dev 16 33-45... 

Human NSCLC cells activitiesj., p-RBj DR4 and DR5T, c-FLIPj TRAIL-induced apoptosis [98]... 

Shi J, Zheng D, Liu Y, Sham MH, Tam P, Farzaneh F, Xu R. Overexpression of soluble TRAIL induces apoptosis in human lung adenocarcinoma and inhibits growth of tumor xenografts in nude mice. Cancer Res 2005 65 1687-1692. 

Zhang, X.D., Franco, A., Myers, K., Gray, C., Nguyen, T., Hersey, P., 1999. Relation of TNF-related apoptosis-inducing ligand (TRAIL) receptor and FLICE-inhibitory protein expression to TRAIL-induced apoptosis of melanoma. Cancer Res. 59, 2747-2753. 

Fulda S, Wick W, Weller M et al (2002) Smac agonists sensitize for Apo2L/TRAIL- or anticancer drug-induced apoptosis and induce regression of malignant glioma in vivo. Nat Med 8(8) 808-815... 

Eggert, A., Grotzer, M.A., Zuzak, T.J., Wiewrodt, B.R., Ikegaki, N., andBrodeur, G., Resistance to TRAIL-induced apoptosis in neuroblastoma cells correlates with a loss of caspase-8 expression. Medical Pediatric Oncol, 35 (6), 603-607, 2000. 

Olsson A, Diaz T, Aguilar-Santelises M. Sensitization to TRAIL-induced apoptosis and modulation of FLICE-inhibitory protein in B chronic lymphocytic leukemia by actino-... 

Kim Y, Suh N, Sporn M, Reed JC. An inducible pathway for degradation of FLIP protein sensitizes tumor cells to TRAIL-induced apoptosis. J Biol Chem 2002 277 22320-22329. 

Chawla-Sarkar M, Bae SI, Reu FJ et al. Downregulation of Bcl-2, FLIP or lAPs (XIAP and survivin) by siRNAs sensitizes resistant melanoma cells to Apo2L/TRAIL-induced apoptosis. Cell Death Differ 2004 11 915-923. 

Miura Y, Koyanagi Y, Mizusawa H. TNF-related apoptosis-inducing ligand (TRAIL) induces neuronal apoptosis in HlV-encephalopathy. Journal of medical and dental sciences 2003a 50(1) 17-25... 

Resveratrol (grape, red wine) HL-60 human leukemia cell line, SHEP neuroblastoma cells Release of cytochrome c from mitochondria, activation of caspases, induction of p53-dependent transcriptional activation sensitizes TRAIL-induced apoptosis decreases in survivin, increases in Smac/DIABLO [155,156]... 

Clancy L. Mruk K, Archer K et al. Preligand assembly domain-mediated ligand-independent association between TRAIL receptor 4 (TR4) and TR2 regulates TRAIL-induced apoptosis. Proc Natl Acad Sci USA 2005 102(50) 18099-18104. 

ToUefimn AE, Toth K, Doronin K et aL Inhibition of TRAIL-induced apoptosis and frirced internalization of TRAIL receptor 1 by adenovirus proteins. J Virol 2IK)1 75(19) 8875-8887. 

In U-937 leukemia cells and mice harboring xenografts of this cell line, the proapoptotic effects of quercetin resulted in both the increased expression of the proapoptotic factor Bax and the inhibition of anti-apoptotic Mcl-l [291]. Quercetin causes apoptosis in both transformed and primary leukemia cells but not in normal blood peripheral mononuclear cells at concentrations up to 50 mM [292]. Further, quercetin has been shown to be a potent enhancer of TRAIL-induced apoptosis in prostate and hepatocellular carcinoma cells [293, 294]. 

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