Inhibition 4- induced lung

K. J. (1990). Time-dependent inhibition of oxygen radical induced lung injury. Inflammation 14, 509-522. 

Poirier LA, Theiss JC, Arnold LJ, et al. 1984. Inhibition by magnesium and calcium acetates of lead subacetate and nickel acetate-induced lung tumors in strain A mice. Cancer Res 44 1520-1522. 

Kodavanti, J. D. Crapo, L. Y. Chang, and K. E. Pinkerton. Inhibition of tobacco smoke-induced lung inflammation by a catalytic antioxidant. Free Radic Biol Med 2002 33(8) 1106-1114. 

Cadalene reduced the incidence of adenomas and inhibited the development of induced lung tumorigenesis in mice [361], while carvacrol inhibited growth of myoblast cells [362]. Menthol exhibited chemopreventive activity against induced rat mammary cancer [363]. 

Smith, T. J., Yang, G., Seril, D. N., Liao, J., and Kim, S. (1998). Inhibition of 4-(methylnitrosamino)-l-(3-pyridyl)-l-butanone-induced lung tumorigenesis by dietary olive oil and squalene. Carcinogenesis 19, 703-706. 

Lung Inhibition of 4-(methylnitrosoamino)-I-(3-pyridyI)-l-butanone (NNK) induced lung tumors [46]... 

Lu G, Liao J, Yang G, Reuhl KR, Hao X, Yang CS. 2006a. Inhibition of adenoma progression to adenocarcinoma in a 4-(methylnitrosamino)-l-(3-pyridyl)-l-buta-none-induced lung tumorigenesis model in A/J mice by tea polyphenols and caffeine. Cancer Res 66 11494—11501. 

Koizumi A, Tsukada M, Hirano S, Kamiyama S, Masuda H, Suzuki KT. Energy restriction that inhibits cellular proliferation by torpor can decrease susceptibility to spontaneous and asbestos-induced lung tumors in AJJ mice. Lab Invest 1993 68 728-739. 

In a murine model of virus-induced lung injury, erythromycin significantly improved survival rate (10). This may be explained by inhibition of inflammatory-cell responses and suppression of nitric oxide overproduction in the lungs of the virus-infected mice. 

Inhibition of azoxymethane (AOM) induced colon tumors Inhibition of Af-methyl-A -nitrosourea (NMU) induced colon tumors Inhibition ofiV-diethylnitrosamine (DEN)/phenobarbital (PB) induced hepatic tumors Inhibition of sponateneous hepatoma development in C3H/HeNCrj mice Inhibition of 4-(methylnitrosoamino)-l-(3-pyridyl)-I-butanone (NNK) induced lung tumors Inhibition of 4-nitroquinoline-W-oxide (4-NQO)/glycerol induced pulmonaiy tumors Inhibition of NMU induced mammary tumors... 

Dietary pretreatment with DDT decreased the incidence of mammary tumors induced by dimethyl benzanthracene (21). Carcinogenicity of ethylene dibromide has been shown (18) to be increased by exposure to disulfiram. Induction of lung benzo(a)pyrene hydroxylase by carbaryl paralleled an Increase in lung tumors induced by benzo(a)pyrene (19). In the same experiments, pretreatment with toxaphene decreased the incidence of lung adenomas (19) and this correlated with the inhibition of lung benzo(a)pyrene hydroxylase. 

Azuma, A., Li,Y. J.,Usuki,J.,Aoyama, A., Enomoto, T., and Kudoh, S. (2001). Fourteen membered-ring macrolides inhibit the VCAM-1 mRNA induction preventing neutrophil induced lung injury and fibrosis in bleomycin challenged mice. Chest 120S, 20-22. 

Castonguay (15A07) described the inhibition in A/J mice of NNK-induced lung tumorigenesis by ellagic acid, a polyphenolic dilactone. 

A09. Chung, F.L., M.A. Morse, K.I. Eklind, and Y. Xu Inhibition of tobacco-specific nitrosamine-induced lung... 

Kavanaugh, B. P., Mouchawar, A., Goldsmith, J., and Pearl, R. G. (1994). Effects of inhaled NO and inhibition of endogenous NO synthesis in oxidant-induced lung injury. J. Appl. Physiol. 76, 1324-1329. 

Verschoyle, R. D., and Dinsdale, D. (1989). Protection against chemical-induced lung injury by inhibition of pulmonary cytochrome P-450, Environ. Health Perspect. 85,95-100. 

PG (58). In subsequent studies (59), we isolated lung myofibroblasts from bleomycin-exposed rats and determined that these cells secreted increased amounts of TGF-pi and PG, as compared to fibroblasts from control animals. PG secretion was further enhanced by exogenous TGF-p and inhibited by anti-TGF-p antibodies and IFN-y. The role of PG is compounded by the ability of decorin to bind TGF-p, reducing its bioavailability (60). A number of studies conducted in transgenic mice have now shown that gene transfer, or transgene overexpression of decorin, can modulate bleomycin-induced lung fibrosis (61-63). 

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