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Hyaluronan biology

Abatengelo, G. and O Reagan, J., Hyaluronan Biological role and function in articular joints. Bur. f. Rheumatol. Injhmm., 15, 6, 1995. [Pg.99]

The biological significance of chitosan biomaterials in the hiunan body depends largely on the actions that certain hydrolases exert on them. The resulting chitoohgomers stimulate various cells, while the released monomers are phosphorylated and incorporated into hyaluronan, keratan sulphate and chondroitin sulphate, components of the intracellular matrix and connective tissue [348]. [Pg.199]

T. C. Laurent, The Chemistry, Biology and Medical Application of Hyaluronan and Its Derivatives. Portland Press, London, 1998. [Pg.212]

Biology, and Medical Applications of Hyaluronan and Its DerivativIsC. Laurent, ed., Portland Press, London, 43-65. [Pg.465]

Abstract Carbohydrates have been investigated and developed as delivery vehicles for shuttling nucleic acids into cells. In this review, we present the state of the art in carbohydrate-based polymeric vehicles for nucleic acid delivery, with the focus on the recent successes in preclinical models, both in vitro and in vivo. Polymeric scaffolds based on the natural polysaccharides chitosan, hyaluronan, pullulan, dextran, and schizophyllan each have unique properties and potential for modification, and these results are discussed with the focus on facile synthetic routes and favorable performance in biological systems. Many of these carbohydrates have been used to develop alternative types of biomaterials for nucleic acid delivery to typical polyplexes, and these novel materials are discussed. Also presented are polymeric vehicles that incorporate copolymerized carbohydrates into polymer backbones based on polyethylenimine and polylysine and their effect on transfection and biocompatibility. Unique scaffolds, such as clusters and polymers based on cyclodextrin (CD), are also discussed, with the focus on recent successes in vivo and in the clinic. These results are presented with the emphasis on the role of carbohydrate and charge on transfection. Use of carbohydrates as molecular recognition ligands for cell-type specific dehvery is also briefly... [Pg.131]

FIGURE 21.1 Scheme for Hyaluronan Catabolism. (Reprinted by the courtesy of the European Journal of Cell Biology, Elsevier Press.)... [Pg.262]

Scott, J.E., Secondary structures in hyaluronan solutions chemical and biological implications, in The Biology of Hyaluronan, Evered, D. and Whelan, J., Eds., John Wiley Sons, Chichester, 1989, p. 16. [Pg.268]

Toole, B.P., Proteoglycans and hyaluronan in morphogenesis and differentiation, in Cell Biology of Extracellular Matrix, Hay, E.D., Ed., Plenum Press, New York, 1991, p. 61. [Pg.268]

Scott, J.E. and Heatley, F., Biological properties of hyaluronan in aqueous solution are controlled and sequestered by reversible tertiary structures, defined by NMR spectroscopy, Biomacromolecules, 3, 547, 2002. [Pg.275]

Asari A (2004) In Garg HG, Hales CA (eds) Chemistry and biology of hyaluronan. Elsevier, Amsterdam, pp 457-468... [Pg.91]

In the discovery and development of hylan A and hylan B, of course, the most important criteria were their purity and biocompatibility. We could never have used these two molecules as therapeutics without the availability of the test that I developed in the late 1960s to monitor the purification process for the native hyaluronan, and producing NIF-NaHA. This test method was accepted by many regulatory agencies as a standard way of proving the biological compatibility of elastoviscous fluids used in ophthalmic... [Pg.142]

The therapeutic use of hyaluronan and its derivatives today is based on the function of this molecule in the healthy body as a stabilizer of the molecular structure of intercellular matrix and as a protector of cells and pain receptors. But we have known for a long time that hyaluronan has other biological functions. We know that elastoviscous solutions of hyaluronan and hylan inhibit certain cell functions by stabilizing the cell membranes. Hyaluronan also interacts with certain proteins that have important functions in the regulation of cell activities. In the future, as we learn more about the function of these specific proteins and how hyaluronan may turn on and off the signals given by these molecules to the cells, we may extend the therapeutic uses of hyaluronan significantly. [Pg.144]

Since the merger, I have continued my research in a non-profit organization, the Matrix Biology Institute (MBI). This research institute that I founded in 1986 carries out fundamental research on the function of the intercellular matrix in general and specifically, on the role of hyaluronan in this matrix. [Pg.145]

Balazs EA, Denlinger JL. Clinical uses of hyaluronan. In Evered D, Whelan I, eds The Biology of Hyaluronan. Chichester Wiley, 1989 265-280. [Pg.682]

In recent years, new biological roles have been ascribed to HA along with its essential function as a component of ECM. Due to its unique rheological properties, hyaluronan has found many applications in pharmacy and medicine. Since it has been reported that biological effects of HA depend on its molar mass, methods of... [Pg.871]

Laurent, T. C. The chemistry, biology and medical applications of hyaluronan and its derivatives. London Portland Press, 1998. [Pg.874]

Sobotka, L. Velebny, V. Ruzickova, J. Kusalova, M. Zadak, Z. In Hyaluronan Structure, Metabolism, Biological Activities, Therapeutic Applications Balazs, E.A. Hascall, V.C., Eds. Matrix Biology Institute Press Edgewater, NJ 2005, pp. 851-853. [Pg.878]


See other pages where Hyaluronan biology is mentioned: [Pg.366]    [Pg.372]    [Pg.97]    [Pg.41]    [Pg.175]    [Pg.156]    [Pg.161]    [Pg.176]    [Pg.245]    [Pg.247]    [Pg.275]    [Pg.223]    [Pg.5628]    [Pg.131]    [Pg.132]    [Pg.134]    [Pg.135]    [Pg.145]    [Pg.175]    [Pg.183]    [Pg.789]    [Pg.875]    [Pg.877]    [Pg.878]    [Pg.878]    [Pg.878]    [Pg.879]    [Pg.880]    [Pg.881]   
See also in sourсe #XX -- [ Pg.246 , Pg.247 , Pg.248 , Pg.249 , Pg.250 , Pg.251 , Pg.252 ]




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