Biological compatibility

Sodium lauryl sulfate is often used in medicinal preparations. As mentioned above, it is used as an emulsifer for creams and lotions in cosmetic preparations, but due to its low toxicity and biological compatibility it is also used in the preparation of creams, gels, and emulsions in which the medications are dispersed. Its ability to lower the interfacial tension affects the potentiation and availability of medications. 

Much of the data reported here was obtained on calcium leucovorin, the stable, isolatable, biologically compatible salt. 

Consider using polyvinyl pyrrolidone (PVP), which is widely used because of its biological compatibility, low toxicity, high complexing power, and its inert behavior toward salts, acids, and thermal degradation [21]. 

Some buffers have excellent characteristics with respect to biologic compatibility and/or buffering features, but they are so expensive that large-scale use is nearly impossible. 

Polyt.V vinyl 2 pyrrolidinnne) (PVP) is undoubtedly the best-characterized and most widely studied (V-vinyl polymer. It derives its commercial success from its biological compatibility, low toxicity, film-forming and adhesive characteristics, unusual complexing ability, relatively inert behavior toward salts and acids, and thermal and hydrolytic stability. 

Some polymers have a specific set of bulk properties that make them ideal for a certain application, but cannot be used because the surface properties are inappropriate. For example, a material may have excellent elasticity but cannot be used in cardiovascular devices because the polymer surface triggers blood clotting. Alternatively, another polymer may have excellent surface biological compatibility but is too brittle for a cardiovascular application. An answer to this problem, like many others, is to select a polymer for its advantageous bulk properties and then carry out property modification reactions on the polymer surface without affecting the bulk material. 

VII. Study of the First Dinuclear N2 Complex with Biologically Compatible Ligand Sphere... 

Among these diazene complexes, the dinuclear analogue of 1(N2H2), [p-N2H2 Fe(NHS4) 2], is the first example in which diazene binds to low-spin Fe(TI) centers carrying only biological compatible donor atoms (see also Section IV. C). 

Another biologically compatible, site-specific method for poly(ethylene glycol) (PEG) conjugation to proteins was described by Sato (2002), who reported the use of the transglutaminase enzyme to catalyze the acyl transfer between the y-carboxyamide group of glutamine and alkylamines under mild conditions. This method could easily be adopted for peptide-PEG conjugation. 

Similarly, Pd-mediated sp2-sp2 C—C (Suzuki-Miyaura) coupling has been enabled in biology through the development of an aqueous biologically compatible Suzuki catalyst system [152], This has now allowed the synthetic glycosylation of whole cell surfaces to create bacterial strains with a synthetic glycocalyx [153],... 

Low, P.S. (1985). Molecular basis of the biological compatibility of nature s osmolytes. In Transport Processes, Iono- and Osmoregulation, pp. 467—477, ed. R. Gilles and M. Gilles-Ballien. Berlin Springer-V erlag. 

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