Intracellular matrix

The biological significance of chitosan biomaterials in the hiunan body depends largely on the actions that certain hydrolases exert on them. The resulting chitoohgomers stimulate various cells, while the released monomers are phosphorylated and incorporated into hyaluronan, keratan sulphate and chondroitin sulphate, components of the intracellular matrix and connective tissue [348]. 

The main drug targets are enzymes and receptors that are found on the cell surface or reside within the intracellular matrix. 

In addition to energy reserves, many other types of biochemicals are required to maintain an organism. Cholesterol is required for cell membrane structure, proteins for muscle contraction, and polysaccharides for the intracellular matrix, to name just a few examples. These substances may be produced from transformed dietary components. 

Diffusion-based methods such as DRYCLEAN are also applicable to cases where the solute of interest, although not having an inherenffy small diffusion coefficient, has an effectively small diffusion coefficient by virtue of its environment (i.e. restricted diffusion such that would occur if the solute were in the intracellular matrix). For example, the intracellular solutes of perfusing cells were able to be selectively observed whilst the extracellular water and solutes in the surrounding medium were suppressed using the stimulated-echo sequence. In a later work Potter et al used the same idea to suppress extracellular water in bacterial suspensions in porous media. 

Skeletal polysaccharides based on pl,4-Dj-mannan and P 1,4-D -xylan backbones exist in the cell walls of red seaweeds which contain agarose or carrageenan in the intracellular matrix. It therefore seems reasonable to suggest that the associations described mimic the natural associations which may exist between the components of the cell wall and the matrix. 

Alginate Alginate is a linear unbranched polysaccharide primarily extracted from brown algae. Within the intracellular matrix of algae, alginate exists as a mixed salt... 

Laurent, T.C. (1970) Structure of hyaluronic acid, in Chemistry and the Molecular Biology of the Intracellular Matrix, (ed. E.A. Balazs). Academic Press, London, pp. 703-732. 

E. A. Balaz (Ed.), "Chemistry and Molecular Biology of the Intracellular Matrix, Vol. 1," Academic Press, New York, 197I. 

In the first place, the choice of a cell line depends on biological requirements of the system to be studied. However, it should be highlighted that with regard to intracellular particle mobility and the degree of autofluorescence, different cell lines can t necessarily be considered equal for optical methods with single molecule sensitivity. Slightly different compositions of the intracellular matrix... 

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