Human adenovirus types

Mitraki, A., Barge, A., Chroboczek, J., Andrieu, J. P., Gagnon, J., and Ruigrok, R. W. (1999). Unfolding studies of human adenovirus type 2 fibre trimers. Evidence for a stable domain. Eur. J. Biochem. 264, 599-606. 

In October 2003, the SFDA approved the world s first gene therapy— Gendicine (a recombinant human adenovirus type 5 mediated delivery of p53 gene)— for the treatment of head and neck cancer. In 2005, another head and neck cancer drug, Oncorine (a recombinant oncolytic adenovirus type 5), was approved. In the same year, another recombinant human endostatin, Endostar, was approved for the treatment of small-cell lung cancer. 

Graham FL, Smiley J, Russel WC, Nairn RJ (1977), Characteristic of a human cell line transformed by DNA from human adenovirus type 5. Gen. Virol. 36 59-72. 

Mostly attenuated organisms are being used as live virus vaccines however, in some instances, even virulent organisms could be used, provided they are not administered via the natural route of infection. For example, human adenovirus types 4 and 7 may cause acute respiratory infections in humans when administered via the oronasal route but provide protection when given orally in enteric-coated capsules. ... 

Mittal, S.K. Papp, Z. Tikoo, S.K. Baca-Estrada, M. Yoo, D. Benko, M. Babiuk, L.A. Induction of systemic and mucosal immune responses in cotton rats immunized with human adenovirus type 5 recombinants expressing the full and secretory forms of bovine herpesvirus type 1 glycoprotein gD. Virology 1996, 222, 299-309. 

Hong, S.S. and Boulanger, P, 1995. Protein ligands of the human adenovirus type 2 outer capsid identified by biopanning of a phage-displayed peptide library on separate domains of wild-type and mutant penton capsomers, EMBO J., 14, pp. 4714-4727. 

McGrory W J, Bautista D S, Graham F L (1988). A simple technique for the rescue of early region 1 mutations into infectious human Adenovirus Type 5. Virol. 163 614-617. 

Fabry CMS, Rosa-Calatrava M, Conway J F, et al. (2005). A quasi-atomic model of human adenovirus type 5 capsid. EMBO J. 24 1645-1654. 

Human adenovirus type 37 (Ad-37) was discovered by de Jong et al. (1981). It causes keratoconjunctivitis and genitourinary tract infections in humans (de Jong et al., 1981). Ad-37 was shown to cause adiposity in chickens (Atkinson et al., 2002). Visceral fat pads were three times heavier for the Ad-37 group compared to the control p < 0.0009). Interestingly, unlike Ad-36, it did not reduce serum cholesterol levels. Food intake of the animals could not explain the adiposity. No information is available about the possible mechanism involved. 

The adipogenic potential of Ad-36 is not shared by all adenoviruses. Avian adenovirus CELO or human adenoviruses type 2 or 31 did not promote adiposity in animal models (Atkinson et al., 2002 Dhurandhar et al., 2000). Unlike Ad-36, Ad-2 and Ad-31 did not show association with human obesity. For Ad-31 and Ad-2 the antibody prevalence between the obese and the nonobese subjects was similar (76% vs SU/o for Ad-2 and 70% and 80% for Ad-31). BMIs and serum lipids were virtually identical for AB- - and AB— subjects (Atkinson et al., 2005). Moreover, almost equal distribution of seropositivity among the obese and nonobese subjects for Ad-2 and Ad-31 suggested that the greater prevalence of Ad-36 antibodies in obese subjects is not a result of obesity. 

Hermiston TW, Hellwig R, Hierholzer JC, Wold WS (1993) Sequence and functional analysis of the human adenovirus type 7 E3-gpl9K protein from 17 clinical isolates. Virology 197 593 600 Hoffman P, Carlin C (1994) Adenovirus E3 protein causes constitutively internalized epidermal growth factor receptors to accumulate in a prelysosomal compartment, resulting in enhanced degradation. Mol Cell Biol 14 3695-3706... 

Mahr JA, Gooding LR (1999) Immune evasion by adenoviruses. Immunol Rev 168 121-130 Marcellus RC, Lavoie. IN, Boivin D, Shore GC, Ketner G, Branton PE (1998) The early region 4 orf4 protein of human adenovirus type 5 induces p53-independent cell death by apoptosis. J Virol 72 7144-7153... 

The ability of two soluble chitosan formulations (chitosan and glycol chitosan) to improve the immunogenicity of an intranasaUy administered replication-defective human adenovirus type 5 expressing BoHV-1 glycoprotein D-based vaccine was investigated in cattle (Vila et al. 2004). It was reported that soluble formulation of glycol chitosan has promising potential use as an intranasal adjuvant for recombinant viral vector vaccines in cattle. 

Gogev, S., K. de Fays, M. F. Versali, S. Gautier, and E. Thiry. 2004. Glycol chitosan improves the efficacy of intranasally administrated rephcation defective human adenovirus type 5 expressing glycoprotein D of bovine herpesvirus 1. Vaccine 22 (15-16) 1946-1953. 

Human adenovirus type 1 Coxsackievirus B1 Black soybean Inhibited human adenovirus type 1 and coxsackievirus B1 in vitro Yamai et al. (2003)... 

Ezoe, H., and Mak, S., 1974, Comparative studies on functions of human adenovirus type 12 and its low oncogenic mutant virions, J. Virol. 14 713. 

Klessig, D. F., and Chow, L. T., 1980, Incomplete splicing and deficient accumulation of the fiber messenger RNA in monkey cells infected by human adenovirus type 2, J. Mol. Biol. 139 221. 

Paraskeva, C., Roberts, C., Briggs, P. and Gallimore, P. H., 1983, Human adenovirus type 2 but not adenovirus type 12 is mutagenic at the hypoxanthine phosphoribosyl transferase locus of cloned rat liver epithelial cells, J. Virol. 46 131. 

Takahashi, M., Ogino, T., Baba, K., and Onaka, M., 1969, Synthesis of deoxyribonucleic acid in human and hamster kidney cells infected with human adenovirus types 5 and 12, Virology 37 513. 

Duncan SJ, Gordon FCA, Gregory DW, McPhie JL, Postlethwaite A, White R and Willcox HNA (1978). Infection of mouse liver by human adenovirus type 5. Journal of General Virology, 40 45-81. 

Torres JM, Alonso C, Ortega A, Mittal S, Graham F and Enjuanes L (1996). Tropism of human adenovirus type 5-based vectors in swine and their ability to protect against transmissible gastroenteritis coronavirus. Journal of Virology, 6 3770-80. 

By the use of UV-inactivated Sendai virus, Yerganian and Nell (1966) have obtained hybrids between somatic cells of the Armenian and Chinese hamsters (transformed by human adenoviruses, types 18 and 7, respectively). Two days after the exposure of die mixed cell suspension to the virus, 18 hybrid metaphases were recorded. These metaphases contained the expected chromosome complements of die two species but these were markedly out of phase with respect to spiralization or contraction of the chromosomes. This asynchrony was apparently transitory, for a second karyological analysis, performed 7 days after exposure of the cells to the virus, showed no such asynchrony in the hybrid metaphases. 

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