Horse chestnut seeds

Herbs rich in podophyllotoxin 3-Aescin (saponin mixture from horse-chestnut seed)... 

The horse chestnut, Aesculus hippocastaneum (Hippocastanaceae), was introduced into the northern Europe from the Near East in the 16th century. Extracts from horse chestnut seeds were already being used therapeutically in France in the early 1800s. Several French works published between 1896 and 1909 reported successful outcomes in the treatment of hemorrhoidal ailments (100). Traditionally, horse chestnut has been used for the treatment of varicose veins, hemorrhoids, phlebitis, diarrhea, fever, and enlargement... 

Schrader E, Schwankl W, Sieder C, Christoffel V. Comparison of the bioavailability of beta-aescin after single oral administration of two different drug formulations containing an extract of horse-chestnut seeds. Pharmazie 1995 50 623-627. 

The edema-reducing effects of class II compression stockings in patients with chronic venous insufficiency have been compared with those given either a placebo or a dried horse chestnut seed extract (HSCE, providing aescin 50 mg twice daily) in a randomized, partially blinded, parallel study. After 12 weeks of therapy, HSCE and compression produced equivalent mean decreases in lower-leg volume (44 and 47 ml, respectively), whereas a mean increase of 10 ml was observed in the placebo group. 

Pittler MH, Ernst E. Horse-chestnut seed extract for chronic venous insufficiency. A criteria-based systematic review. Arch Dermatol 1998 134(ll) 1356-60. 

Horse chestnut (Aesculus hippocastanum) is a source of esculine, an extract from the common horse chestnut seed. Along with ximenynic and lauric acids, esculin has markedly reduced hair loss in male pattern balding. The preparation has improved scalp circulation, reduced seborrhea, and improved the hair s vitality. 

Hamamelidis folium Harpagophyti radix Hippocastani semen Horse-Chestnut Seed Iceland Moss Ispaghula Husk Juniper Berries Lichen islandicus Linseed... 

Diehm C, Trampisch HJ, Lange S, Schmidt C. Comparison of leg compression stocking and oral horse-chestnut seed extract therapy in patients with chronic venous insufficiency. Lancet 1996 347 292-294. 

Fig. 1,2,3 Hippocastani semen Horse chestnut seeds Aesculus hippocastanum L. Hippocastanaceae DAB 10, MD...

Horse chestnut seeds are considered inedible and poisonous. The bitter flavor prevents consumption of large amounts. The leaves, flowers, young sprouts, and seeds are toxic. Symptoms of poisoning include nervous muscle twitching, weakness, dilated pupils, vomiting, diarrhea, depression, paralysis, and stupor (HARDIN AND arena). Incidents of anaphylactic shock after i.v. injections of horse chestnut have been reported, along with renal toxicity or failure (frohne and pfander). Horse chestnut pollens are also a common cause of aller-gic condition in urban children. 

Acetic acid occurs naturally in many plant species including Merrill flowers Telosma cordata), in which it was detected at a concentration of 2,610 ppm (Furukawa et al., 1993). In addition, acetic acid was detected in cacao seeds (1,520 to 7,100 ppm), celery, blackwood, blueberry juice (0.7 ppm), pineapples, licorice roots (2 ppm), grapes (1,500 to 2,000 ppm), onion bulbs, oats, horse chestnuts, coriander, ginseng, hot peppers, linseed (3,105 to 3,853 ppm), ambrette, and chocolate vines (Duke, 1992). 

Gastrointestinal Direct stomach irritation -nausea, vomiting and diarrhea California buckthorn (sacred bark), tung nut, horse chestnut, pokeweed Emodin and esculine (toxins) oil from seeds, nuts some medical uses Children are most often affected... 

Plant materials often contain triterpenoid saponin in considerable amounts. With regard to plants with antiulcer activity, licorice root contains about 2 to 12% of glycyrrhizic acid and the seeds of the horse chestnut up to 13% of aescin. Several plants containing high amounts have been shown to possess antiulcer activity in several experimental ulcer models (Table 64.2). 

Aescin is a complex mixture of triterpene saponins prepared from the seeds of the horse chestnut, Aesculus hippocastanum. It consists of a water-soluble fraction (alpha-aescin) and a water-insoluble fraction (beta-aescin). 

Clinically important, potentially hazardous interactions with acenocoumarol, aspirin, bivalirudin, butabarbital, capsicum, ceftobiprole, dabigatran, danaparoid, desvenlafaxine, dong quai, ginger, horse chestnut (bark, flower, leaf, seed), palifermin, red clover, salicylates, tazobactum, tirofiban... 

HORSE CHESTNUT, AescuU semen is the seed of Aesculus hippocastanum (L.), family Hippocastanaceae. The seed contains a triterpene saponin mixture usually referred to as Aescin. Aescin gives prolonged... 

CAS 6805-41-0 EINECS/ELINCS 229-880-6 Definition Saponin occurring in the seed of the horse chestnut tree, Aesculus hippocastanum Empirical C54H84O23... 

Constit. of seeds of horse chestnut, onions and roots of Asparagus (Liliaceae). Sweetening agent for food and chewing gum. Constit. of neosugar which improves the intestinal flora in humans. Needles + 3H2O (MeOH aq.), cryst. -I- IH2O. Mp 134° (trihydrate), Mp 129-131° (monohydrate). [a]j> + 10 (c, 0.36 in H2O). 

Aesculus hippocastanum Horse chestnut Aescin source Seeds 10... 

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