High-fat-diet -induced obesity

HAN L K, ZHENG Y N, XU B J, OKUDA H, KiMURA Y (2002) Saponins from platycodi radix ameliorate high fat diet-induced obesity in mice. JNutr. 132 2241-5. 

Table 7.6 Effect of dietary colestimide on biochemical measures in diabetic NSY mice both during and following high-fat diet induced obesity." ...

Kalupahana, N. S., Claycombe, K., Newman, S. J., Stewart, T., Siriwardhana, N., Matthan, N., Lichtenstein, A. H., and Moustaid-Moussa, N. (2010b). Eicosapentaenoic acid prevents and reverses insulin resistance in high-fat diet-induced obese mice via modulation of adipose tissue inflammation. J. Nutr. 140,1915-1922. 

It is well accepted that hyperphagia, the increased consumption of a high-fat diet and hyperinsulinemia contribute to the development of obesity. We designed two animal models of obesity gold thioglucose (GTG)-induced obesity and high-fat diet-induced obesity in mice. We examined the anti-obesity effects of natural products in these models. 

In brief, ezetimibe suppresses fatty acid and TG synthesis, and may thus reverse the dyslipidemia in high-fat-diet-induced obese mice via a pathway involving SHP and SREBP-lc. 

Selective tools have helped determine possible roles of each ERR family member. ERRa knockout mice show relatively normal anatomical features, but have much lower fat deposits than wild-type mice and are resistant to high-fat diet-induced obesity, suggesting a role for ERRoc in metabolic regulation [39]. The mice also lack the ability to maintain body temperature due to defects in mitochondrial function [39]. ERRp knockout mice die before birth, suggesting an important role for ERRP during embryonic development [40]. The ERRy knockout mice die within 1 week after birth due to faulty oxidative metabolism in the heart [41]. 

Lin, S., Thomas, T.C., Storlien, L.H. and Huang, X.E (2000) Development of high fat diet-induced obesity and leptin resistance in C57B1/6J mice, Int J Obes Relat Metab Disord, 24 639-46. 

Cani, P. D., BibUoni, R., Knauf, C., Waget, A., Neyrinck, A. M., Delzenne, N. M., et al. (2008). Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice. Diabetes, 57(6), 1470-1481. 

Ibarra A, Bai N, He K, Bily A, Cases J, Roller M, Sang S (2011) Fraxinus excelsior seed extract FraxiPure limits weight gains and hyperglycemia in high-fat diet-induced obese mice. Phytomedicine 18 479 85... 

Also, GA given to high-fat-induced obese rats led to significant reduction in blood pressure and improvement in HOMA-IR (p < 0.05). LPL expression was upregulated in the K, H, QF, AM, VAT, and SAT but downregulated in the L - a condition seen in reverse to that seen in high-fat diet-induced obese rats... 

Jeong S, Yoon M (2009) Fenofibrate inhibits adipocyte hypertrophy and insulin resistance by activating adipose PPARa in high fat-diet induced obese mice. Exp Mol Med 41(6) 397-405... 

Preitner, R, Mody, N., Graham, T. E. et al. 2009. Long-term Eemetinide treatment prevents high-fat diet-induced obesity, insubn resistance, and hepatic steatosis. Am J Physiol Endocrinol Metab 297 E1420-E1429. 

Tanshinone IIA Salvia miltiorrhiza Antagonist 3.90 Improves glucose tolerance in a high-fat-diet-induced obese animal model [52]... 

Matsui, N., Ito, R., Nishimura, E., and Yoshikawa, M. 2005. Ingested cocoa and prevent high-fat diet-induced obesity by regulating the expression on genes for fatty acid metabolism. Nutrition 27 594-601. 

Simg, Y. Y., Kim, D. S., Kim, H. K., (2014). Viola mandshurica ethanolic extract prevents high-fat-diet-induced obesity in mice by activating AMP-activated protein kinase. Environ. Toxicol. Pharmacol. 38,41-50. 

---