Diet-induced obesity

HAN L K, ZHENG Y N, XU B J, OKUDA H, KiMURA Y (2002) Saponins from platycodi radix ameliorate high fat diet-induced obesity in mice. JNutr. 132 2241-5. 

Ziouzenkova, O., G. Orasanu, M. Sharlach et al. 2007a. Retinaldehyde represses adipogenesis and diet-induced obesity. Nat Med 13(6) 695-702. 

High-fat diet studies with DGATl-/- and DGATl+/- mice demonstrated that the absence of DGAT1 activity may lead to increased insulin sensitivity, leptin sensitivity, protection against diet-induced obesity, and protection against liver steatosis [40-43]. 

Um, S. H., Frigerio, F., Watanabe, M., Picard, F., Joaquin, M., Sticker, M., Fumagalli, S., Allegrini, P. R., Kozma, S. C., Auwerx, J., and Thomas, G. (2004). Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity. Nature... 

An early biphenyl candidate, A-331440 (6) has been reported to be a competitive, potent inverse agonist with balanced activity at human and rat H3Rs with good oral bioavailability [40]. While A-331440 was active in obesity models, its development was precluded by genotoxicity issues [41], The latter was eliminated by a tactical orf/zo-substitution on the phenoxy central core by fluorine to provide A-417022 (7). A-417022 and the 3,5-difluoro analog (A-423579) also produced prolonged weight loss over a 28-day period in a rat diet-induced obesity model [17,41],... 

Kang, D. H., Jung, E. Y., Chang, U. J., Bae, S. H., and Suh, H. J. (2007). Psyllium husk combined with hydroxycitrate reduces body weight gain and body fat in diet-induced obese rats. Nutr. Res. 27, 349-355. 

Table 7.6 Effect of dietary colestimide on biochemical measures in diabetic NSY mice both during and following high-fat diet induced obesity." ...

Yang R, Castriota G, Chen Z et al (2011) RNAi-mediated germlme knockdown of FABP4 increases body weight but does not improve the deranged nutrient metabolism of diet-induced obese mice. Int J Obes 35 217-225... 

Prunet-Marcassus et al Melatonin reduces body weight gain in Sprague-Dawley rats with diet-induced obesity. Endocrinology 2003 144 5347. [PMID 12970162]... 

Kalupahana, N. S., Claycombe, K., Newman, S. J., Stewart, T., Siriwardhana, N., Matthan, N., Lichtenstein, A. H., and Moustaid-Moussa, N. (2010b). Eicosapentaenoic acid prevents and reverses insulin resistance in high-fat diet-induced obese mice via modulation of adipose tissue inflammation. J. Nutr. 140,1915-1922. 

This chapter will present methods that are widely used for screening and validating new therapeutic drugs using in vivo mouse models. These models can roughly be divided in two types first, genetic models where animals develop symptoms of diabetes, even in absence of environmental changes, and second, diet-induced obesity, which results in increased insulin resistance (see Note 1). 

C57BL/6J is one of the most commonly used mouse strains for diabetes studies. Diet-induced obesity in this strain causes hyperglycemia, hyperinsulinemia, and the development of a fatty liver. One shortcoming of this model, however, is that diet alone is insufficient for the symptoms to progress to a later stage disease, such as beta-cell degeneration and diabetic nephropathy. 

Involvement of sex, strain and age factors in high lat diet-induced obesity in C57BL/6 J and BALB/cA mice. Exp Anim 56, 263-272. 

Gregoire, F. M., Zhang, Q., Smith, S. J., Tong, C., Ross, D., et al. (2002) Diet-induced obesity and hepatic gene expression alterations in C57BL/6 J and ICAM-1-deficientmice. Am J Physiol Endocrinol Metab 282, E703-713. 

Huggins, K. W., Boileau, A. C., and Hui, D. Y. (2002) Protection against diet-induced obesity and insulin resistance in group IB PLA2 deficient mice. Am. J. Physiol. Endocrinol. Metab. 283, E994-E1001. 

LaBonte, E. D., Camarota, L. M., Rojas, J. C., Jandacek R. J., Gilham, D.E., et al. (2008) Reduced absorption of saturated fatty acids and resistance to diet-induced obesity and diabetes by ezetimibe-treated and... 

Sedova, L., Berube, J., Gaudet, D., Dumont, M., Tremblay, J., Hamet, P., and Pausova, Z. 2004. Diet-induced obesity delays cardiovascular recovery from stress in spontaneously hypertensive rats. Obes. Res. 12 1951-1958. 

Table 2 Effect on body fat mass and lean body mass for diet-induced obese mice using Entry 1 for 3 weeks at lOmg/kg per day...

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