Prostate cancer mortality

A number of epidemiologic studies support an association between high fat intake and the risk of prostate cancer. A strong correlation between national per capita fat consumption and national prostate cancer mortality has been reported, and prospective case-control studies suggest that a high-fat diet doubles the risk of prostate cancer. 

Perron L, Moore L, Bairati I, Bernard P-M, Meyer F, PSA screening and prostate cancer mortality, CMAJ, 166 586-591, 2002. 

H4. Hanchette, C. L., and Schwartz, G. G., Geographic patterns of prostate cancer mortality Evidence for a protective effect of ultraviolet radiation. Cancer 70, 2861-2869 (1992). 

Several epidemiological studies on the effects of PPOA in humans have been conducted on workers. These studies did not examine developmental outcomes. A retrospective cohort mortality study demonstrated a statistically significant association between prostate cancer mortality and employment duration in the chemical facility of a plant that manufactures PPOA. However, this result was not observed in an update to the study in which more specific exposure measures were used. 

C. Bouchardy, G. Fioretta, E. Rapiti, H.M. Verkooijen, C.H. Rapin, F. Schmidlin, et al.. Recent rends in prostate cancer mortality show a continuous decrease in several countries, Int. J. Gancer 123 (2008) 421. 

Hebert, J.R., Hurley, T.G., Olendzki, B.C., Teas, J., Ma, Y., and Hampl, J.S., Nutritional and socioeconomic factors in relation to prostate cancer mortality A cross-national study, J. Natl. Cancer Inst., 90, 1637-1647,1998. 

In 1998, a study was published on prostate cancer, the most prevalent cancer among men. Prostate cancer represents a large and growing health problem in the United States and other western countries [142]. In this large, 59-country study, Hebert et al. [142] tried to identify predictive measures for prostate cancer mortality. They concluded by staling that the results from this study are consistent with previous information and support the hypothesis that grains, cereals, and nuts are protective against prostate cancer [142]. 

In countries such as Japan, although the incidence of latent, small or non-infiltrative prostate cancer is similar to that found in Western countries, the incidence of invasive cancer and associated mortality is far lower (Adlercreutz and Mazur, 1997). In Japan, diets have traditionally included large amounts of soy, and it has been proposed that this may be responsible for the protective effect. To date, however, the results are inconsistent, although there may be an inverse correlation with non-fermented soy foods. The active component... 

Smoking has not been associated with an increased risk of prostate cancer, but smokers with prostate cancer have an increased mortality resulting from the disease when compared... 

DES was once a mainstay of prostate cancer therapy. While very effective in androgen ablation, DES-treated patients experienced increased cardiovascular mortality.41 LHRH agonists, with equivalent efficacy and decreased cardiovascular toxicity, supplanted DES as a mainstay of therapy. 

A study of cancer mortality among 1359 workers involved in the production of acetic acid and acetic anhydride found that mortality from all causes decreased but mortality ftom prostate cancer was significantly increased, based on six deaths. Measurements of acetic acid levels were not made for most of the study period, but recent monitoring found exposures ranging between 0.1 and 1.2 ppm. ... 

Prostate cancer is the most frequently diagnosed malignancy in males and ranks second only to lung cancer in terms of annual mortality. Great efforts have been made in the past to develop novel approaches to the treatment of prostate cancer. The two main options for the treatment of prostate cancer are... 

FMCa Flavonols Flavones Flavanones 24-26-28 9131 M-F Reduction of total mortality, lung cancer, prostate cancer arthritis, asthma, coronary heart disease (161-163)... 

Two types of epidemiological relationships have been found in two different populations. Both relationships were inverse to selenium bioavailability and paralleled the results from animal studies. In one type of study, selenium bioavailability has been inversely related to human cancer mortality in American cities and states (14-15). Schrauzer et.al. correlated the age-adjusted mortality from cancer at 17 major body sites with the apparent dietary selenium intakes estimated from food consumption data in 27 countries (16). Significant inverse correlations were observed for cancers of the large intestine, rectum, prostate, breast, ovary, lung, and leukemia. In addition, weaker inverse associations were found for cancers of the pancreas, skin, and bladder. 

H10. Heinonen, O. P., Albanes, D., Virtamo, J., Taylor, P. R., Huttunen, J. K., etal., Prostate cancer and supplementation with alpha-tocopherol and beta-carotene Incidence and mortality in a controlled trial. J. Natl. Cancer Inst. 90, 440 146 (1998). 

Prostate cancer incidence and mortality vary in different countries and racial groups, and this implicates not only genetic or hereditary differences but also environmental and dietary factors. American Blacks have the highest incidence and mortality, followed by Whites and lastly Asians. Black and Asian Americans... 

---