High-fat diet-induced model

It is well accepted that hyperphagia, the increased consumption of a high-fat diet and hyperinsulinemia contribute to the development of obesity. We designed two animal models of obesity gold thioglucose (GTG)-induced obesity and high-fat diet-induced obesity in mice. We examined the anti-obesity effects of natural products in these models. 

Almost all of the work examining modulation of xenobiotic-induced hepatotoxicity in diabetes has been done using type 1 diabetic models. Recently, a study reported a novel high-fat diet-induced type 2 diabetic rat model and tested the susceptibility of these diabetic rats to several classical hepatotoxicants. On treatment with nonlethal or sublethal doses of allyl alcohol, CCI4, or thioacetamide, it was found that hepatotoxicity of all these toxicants is significantly increased in the type 2 diabetic rats. 

Tanshinone IIA Salvia miltiorrhiza Antagonist 3.90 Improves glucose tolerance in a high-fat-diet-induced obese animal model [52]... 

Ju J, Liu Y, Hong J, Huang MT, Conney AH, Yang CS. 2003. Effects of green tea and high-fat diet on arachidonic acid metabolism and aberrant crypt foci formation in an azoxymethane-induced colon carcinogenesis mouse model. Nutr Cancer 46 172-178. 

Xi S, Yin W, Wang Z, Kusunoki M, Lian X, Koike T, Fan J, Zhang Q (2004) A minipig model of high-fat/high-sucrose diet-induced diabetes and atherosclerosis. Int J Expt Patho 85(4) 223-231... 

In the present review, we focused on scientific studies of selected phytocompounds and their ability to target insulin resistance. Twenty-six selected phytocompounds have been investigated either in vivo using various animal models streptozotocin-induced diabetic rats, high-fat diet mice and rats, and C57BLKS/J db/db mice or in vitro using some cellular lines essentially... 

---