High-content screening

Additional methods for measuring GPCR activation are reviewed in Sect. 6.3.3 on High Content Screening. [Pg.47]

Cik M, Jurzak MR (2006) High-throughput and high content screening. In Taylor JB, Triggle DJ (eds) Comprehensive medicinal chemistry II. Elsevier, Oxford, Sect 3.32... [Pg.172]

Edwards BS, Oprea T, Prossnitz ER, Sklar LA. Flow cytometry for high-throughput, high-content screening. Curr Opin Chem Biol 2004 8 392-398. [Pg.388]

High-content screening, siRNA screening, Target discovery... [Pg.97]

The siRNA screening is performed in duplicate in 96-well plates as shown in Fig. 1. The first replica is used for viability readout and the second for phenotypic readout where we look at spindle structure by using a high content screening platform. The small molecule library screening is also performed in duplicate with the first replica used for viability readout. In contrast to the siRNA... [Pg.98]

Black wall, clear bottom 96-well tissue culture plates to be read by a suitable high content screening platform. [Pg.100]

CellProfiler and KNIME Open Source Tools for High Content Screening... [Pg.105]

Key words High content screening. Image processing. Statistics, Open Soiuce, CeUProfiler, KNIME,... [Pg.105]

Giuliano KA, DeBiasio RL, Dunlay RT et al (1997) High-content screening a new approach to easing key bottlenecks in the drug discovery process. J Biomol Screen 2 249... [Pg.121]

Bray M-A, Fraser AN, Hasaka TP et al (2011) Workflow and metrics for image quality control in large-scale high-content screens. J Biomol Screen 17 135-143... [Pg.122]

Quintavalle M, Elia L, Price JH et al (2011) A cell-based high-content screening assay reveals activators and inhibitors of cancer cell invasion. Sci Signal 4 ra49... [Pg.248]

Bartholoma P, Impidjati, Reininger-Mack A et al (2005) A more aggressive breast cancer spheroid model coupled to an electronic capillary sensor system for a high-content screening of cytotoxic agents in cancer... [Pg.249]

Giuliano, K.A., Johnston, P.A., Gough, A. and Taylor, D.L. (2006) Systems cell biology based on high-content screening. Methods in Enzymology, 414, 601-619. [Pg.69]

Abraham, V.C., Taylor, L. and Haskins, J.R. (2004) High content screening applied to large-scale cell biology. Trends in Biotechnology, 22, 15-72. [Pg.343]

O Brien, P.J. (2008) Chapter 13 High content analysis of sublethal cytotoxicity in human HepG2 hepatocytes for assessing potential and mechanism for chemical and drug-induced human toxicity, in High Content Screening Science, Techniques and Applications (ed. S.A. Haney), John Wiley Sons, Hoboken, NJ,... [Pg.343]

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