High content screening image-based

Several direct dye staining procedures can measure total protein biomass, nucleic acid content, or selective uptake by organelles such as mitochondria or lysosomes. Many staining methods are appropriate for small numbers of samples or for image-based high content screening but in most cases, the multistep procedures exhibit limitations for HTS. 

The application of emerging technologies and systems, including image-based high-content screening, RNA interference, and primary cells... 

Chapter 8 Image-Based High-Content Screening.143... 

High-content screen (HCS) is a phenotypic screening that monitors multiple cellular parameters simultaneously. HCS employs fluorescence-based reagents (antibodies, dyes that bind or localize to a given cell component, sensors) to generate a multicolor fluorescence readout that is usually recorded using automated optical image acquisition devices. 

Informatics for High Content Image-Based Screening.256... 

INFORMATICS FOR HIGH CONTENT IMAGE-BASED SCREENING... 

Donato MT, Tolosa L, Jimenez N, Castell JV, G6mez-Lech6n MJ (2012) High-content imaging technology for the evaluation of drug-induced steatosis using a multiparametric cell-based assay. J Biomol Screen 17, 394-400. 

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