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High content analysis

Key words High content analysis, Protein fragment complementation. Protein-protein interactions. [Pg.179]

There are a number of stains to label the nucleus for the purpose of detection in high content analysis. We use DRAQ5 to label not only the nuclei but also the cytosol to a lesser extent. With thresholds properly adjusted, imaging software can detect the nuclei and cytosol in the same channel in two consecutive steps with just one staining. [Pg.184]

O Brien, P.J. (2008) Chapter 13 High content analysis of sublethal cytotoxicity in human HepG2 hepatocytes for assessing potential and mechanism for chemical and drug-induced human toxicity, in High Content Screening Science, Techniques and Applications (ed. S.A. Haney), John Wiley Sons, Hoboken, NJ,... [Pg.343]

O Brien, P.J. and Domingos, M.C. (2009) Use of high content analysis in toxicologic clinical pathology for identification and monitoring of translational safety biomarkers. American Drug Discovery... [Pg.343]

Denner, P, Schmalowsky, J., and Prechtl, S. 2008. High-content analysis in preclinical drug discovery. Comb. Chem. High-Throughput Screen. 11, 216-230. [Pg.260]

Radio NM, Freudenrich TM, Robinette BL, Crofton KM, Mundy WR (2010) Comparison of PC12 and cerebellar granule cell cultures for evaluating neurite outgrowth using high content analysis. Neurotoxicol Teratol 32 25-35... [Pg.142]

Persson, M. et al., 2014. High-content analysis/screening for predictive toxicology application to hepatotoxicity and geno-toxicity. Basic Clinical Pharmacology Toxicology, 115(1), pp. 18-23. [Pg.91]

O Brien PJ (2014) High-content analysis in toxicology screening substances for human toxicity potential, elucidating subcellular mechanisms and in vivo use as translational safety biomarkers. Basic Clin Pharmacol Toxicol 115, 4-17. [Pg.126]


See other pages where High content analysis is mentioned: [Pg.407]    [Pg.105]    [Pg.179]    [Pg.179]    [Pg.325]    [Pg.327]    [Pg.391]    [Pg.596]    [Pg.597]    [Pg.852]    [Pg.274]    [Pg.275]    [Pg.225]    [Pg.424]    [Pg.459]    [Pg.53]    [Pg.46]   
See also in sourсe #XX -- [ Pg.105 , Pg.179 , Pg.184 ]

See also in sourсe #XX -- [ Pg.597 , Pg.610 ]




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